TY - JOUR
T1 - The liberated domain I of urokinase plasminogen activator receptor--a new tumour marker in small cell lung cancer
AU - Almasi, Charlotte E
AU - Drivsholm, Lars
AU - Pappot, Helle
AU - Høyer-Hansen, Gunilla
AU - Christensen, Ib J
PY - 2013/3
Y1 - 2013/3
N2 - The prognosis of small cell lung cancer (SCLC) remains poor with a 5-year survival rate of 4-6%. In non-small cell lung cancer (NSCLC), high levels of intact and cleaved forms of the receptor for urokinase plasminogen activator (uPAR) are significantly associated with short overall survival. Our aim was therefore to determine the prognostic value of the different uPAR forms in blood from SCLC patients. Serum samples from 92 treatment naive SCLC patients were analysed. Intact uPAR, uPAR(I-III), intact and cleaved uPAR, uPAR(I-III) + uPAR(II-III) and the liberated domain I, uPAR(I) were measured using time-resolved fluorescence immunoassays (TR-FIA 1-3). Assessment of association of the uPAR forms to overall survival (OS) was done using Cox regression analysis adjusted for clinical covariates [age, gender, stage, lactate dehydrogenase (LDH), WHO performance status (PS)]. Multivariate survival analysis demonstrated that high levels of uPAR(I) were significantly (p = 0.009) associated with short overall survival (OS). Patients with uPAR(I) levels above the second tertile had a hazard ratio (HR) of 1.9 (95% confidence interval (CI): 1.1-3.3), compared to patients with levels below the first tertile. High serum uPAR(I) levels are associated with short OS in SCLC patient, independent of LDH and PS.
AB - The prognosis of small cell lung cancer (SCLC) remains poor with a 5-year survival rate of 4-6%. In non-small cell lung cancer (NSCLC), high levels of intact and cleaved forms of the receptor for urokinase plasminogen activator (uPAR) are significantly associated with short overall survival. Our aim was therefore to determine the prognostic value of the different uPAR forms in blood from SCLC patients. Serum samples from 92 treatment naive SCLC patients were analysed. Intact uPAR, uPAR(I-III), intact and cleaved uPAR, uPAR(I-III) + uPAR(II-III) and the liberated domain I, uPAR(I) were measured using time-resolved fluorescence immunoassays (TR-FIA 1-3). Assessment of association of the uPAR forms to overall survival (OS) was done using Cox regression analysis adjusted for clinical covariates [age, gender, stage, lactate dehydrogenase (LDH), WHO performance status (PS)]. Multivariate survival analysis demonstrated that high levels of uPAR(I) were significantly (p = 0.009) associated with short overall survival (OS). Patients with uPAR(I) levels above the second tertile had a hazard ratio (HR) of 1.9 (95% confidence interval (CI): 1.1-3.3), compared to patients with levels below the first tertile. High serum uPAR(I) levels are associated with short OS in SCLC patient, independent of LDH and PS.
KW - Adult
KW - Aged
KW - Female
KW - Humans
KW - L-Lactate Dehydrogenase
KW - Lung Neoplasms
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Prognosis
KW - Protein Structure, Tertiary
KW - Receptors, Urokinase Plasminogen Activator
KW - Regression Analysis
KW - Small Cell Lung Carcinoma
KW - Tumor Markers, Biological
U2 - 10.1111/j.1600-0463.2012.02955.x
DO - 10.1111/j.1600-0463.2012.02955.x
M3 - Journal article
C2 - 23030781
SN - 0903-4641
VL - 121
SP - 189
EP - 196
JO - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
IS - 3
ER -
