TY - JOUR
T1 - The lack of sustained effect of bright light in non-seasonal major depression
AU - Martiny, Klaus
AU - Lunde, Marianne
AU - Undén, Mogens
AU - Dam, Henrik
AU - Bech, Per
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Background. Recently accumulated evidence has demonstrated that bright-light therapy in combination with antidepressants is effective in patients with non-seasonal major depression. Whether bright light has a sustained effect after discontinuation is, however, poorly investigated. Method. In this double-blind randomized study we report the results from a 4-week follow-up period in patients with major non-seasonal depression who had been treated for 5 weeks with sertraline combined with bright-light therapy or sertraline combined with dim-light therapy. At the beginning of the follow-up period the light therapy was stopped while sertraline treatment continued for 4 weeks. Results. Depression scores decreased substantially in both groups, resulting in high response and remission rates in both groups after 9 weeks of treatment. The difference in depression scores at week 5, favouring the bright-light-treated group, disappeared gradually in the 4-week follow-up period, resulting in similar end-point scores. Conclusions. Bright light did not have a sustained effect after discontinuation. The offset of effect was complete after 4 weeks.
AB - Background. Recently accumulated evidence has demonstrated that bright-light therapy in combination with antidepressants is effective in patients with non-seasonal major depression. Whether bright light has a sustained effect after discontinuation is, however, poorly investigated. Method. In this double-blind randomized study we report the results from a 4-week follow-up period in patients with major non-seasonal depression who had been treated for 5 weeks with sertraline combined with bright-light therapy or sertraline combined with dim-light therapy. At the beginning of the follow-up period the light therapy was stopped while sertraline treatment continued for 4 weeks. Results. Depression scores decreased substantially in both groups, resulting in high response and remission rates in both groups after 9 weeks of treatment. The difference in depression scores at week 5, favouring the bright-light-treated group, disappeared gradually in the 4-week follow-up period, resulting in similar end-point scores. Conclusions. Bright light did not have a sustained effect after discontinuation. The offset of effect was complete after 4 weeks.
UR - http://www.scopus.com/inward/record.url?scp=33746865606&partnerID=8YFLogxK
U2 - 10.1017/S0033291706008105
DO - 10.1017/S0033291706008105
M3 - Journal article
C2 - 16756691
AN - SCOPUS:33746865606
SN - 0033-2917
VL - 36
SP - 1247
EP - 1252
JO - Psychological Medicine
JF - Psychological Medicine
IS - 9
ER -