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The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation
Ara M. Abramyan, Sebastian Stolzenberg, Zheng Li,
Claus J. Loland
, Frank Noe, Lei Shi
Neuropharm and Genetics
16
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Keyphrases
Dopamine Transporter
100%
Dopamine Reuptake Inhibitor
100%
Isomeric
100%
Open Conformation
60%
Molecular Dynamics Simulation
40%
Cocaine
40%
Benztropine
40%
Modeling Analysis
20%
Computational Simulation
20%
Conformational Equilibrium
20%
Inhibition Mechanism
20%
Quantum Mechanical Calculations
20%
Psychostimulants
20%
Simulation Approach
20%
Rational Design
20%
Mechanistic Details
20%
Computational Modeling Methods
20%
Tropane
20%
Stereoisomeric
20%
Molecular Mechanism
20%
Biochemistry, Genetics and Molecular Biology
Dopamine Transporter
100%
Conformation
100%
Computer Simulation
28%
Wild Type
14%
Neuroscience
Dopamine Transporter
100%
Tropane
14%
Psychostimulant
14%
Medicine and Dentistry
Benzatropine
28%
Cocaine Derivative
14%
Tropane Derivative
14%