The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells

B Brock; Søren Gregersen; K Kristensen; J L Thomsen; K Buschard; Hans Kofod; K Hermansen

doi:10.1007/s001250051442

The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells

B Brock, Søren Gregersen, K Kristensen, J L Thomsen, K Buschard, Hans Kofod, K Hermansen

Inflammation, Metabolism and Oxidation

14 Citationer (Scopus)

Abstract

The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be an insulinotropic agent. The mechanism of action of endothelin-1 on the endocrine pancreas has not yet been clarified.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	42
Udgave nummer	11
Sider (fra-til)	1302-7
Antal sider	6
ISSN	0012-186X
DOI	https://doi.org/10.1007/s001250051442
Status	Udgivet - nov. 1999

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10.1007/s001250051442

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title = "The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells",

abstract = "The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be an insulinotropic agent. The mechanism of action of endothelin-1 on the endocrine pancreas has not yet been clarified.",

keywords = "Animals, Cell Line, Endothelin-1, Glucagon, Insulin, Islets of Langerhans, Male, RNA, Messenger, Rats, Rats, Inbred Lew, Receptor, Endothelin A, Receptors, Endothelin, Reverse Transcriptase Polymerase Chain Reaction",

author = "B Brock and S{\o}ren Gregersen and K Kristensen and Thomsen, {J L} and K Buschard and Hans Kofod and K Hermansen",

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doi = "10.1007/s001250051442",

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T1 - The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells

AU - Brock, B

AU - Gregersen, Søren

AU - Kristensen, K

AU - Thomsen, J L

AU - Buschard, K

AU - Kofod, Hans

AU - Hermansen, K

PY - 1999/11

Y1 - 1999/11

N2 - The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be an insulinotropic agent. The mechanism of action of endothelin-1 on the endocrine pancreas has not yet been clarified.

AB - The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be an insulinotropic agent. The mechanism of action of endothelin-1 on the endocrine pancreas has not yet been clarified.

KW - Animals

KW - Cell Line

KW - Endothelin-1

KW - Glucagon

KW - Insulin

KW - Islets of Langerhans

KW - Male

KW - RNA, Messenger

KW - Rats

KW - Rats, Inbred Lew

KW - Receptor, Endothelin A

KW - Receptors, Endothelin

KW - Reverse Transcriptase Polymerase Chain Reaction

U2 - 10.1007/s001250051442

DO - 10.1007/s001250051442

M3 - Journal article

C2 - 10550413

SN - 0012-186X

VL - 42

SP - 1302

EP - 1307

JO - Diabetologia

JF - Diabetologia

IS - 11

ER -

The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells

Abstract

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