The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease

Naja Dam Mygind; Marina J Harutyunyan; Anders Bruun Mathiasen; Rasmus Sejersten Ripa; Jens Jacob Thune; Jens Peter Gøtze; Julia S Johansen; Jens Kastrup; The CLARICOR Trial Group

doi:10.1007/s00011-010-0266-5

The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease

Naja Dam Mygind, Marina J Harutyunyan, Anders Bruun Mathiasen, Rasmus Sejersten Ripa, Jens Jacob Thune, Jens Peter Gøtze, Julia S Johansen, Jens Kastrup, The CLARICOR Trial Group

42 Citationer (Scopus)

Abstract

OBJECTIVE: The inflammatory biomarker YKL-40 is elevated and associated with mortality in patients with stable coronary artery disease (CAD). The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD. DESIGN: Serum YKL-40, HsCRP, total cholesterol, HDL-c, LDL-c and triglycerides levels were measured in 404 statin treated and in 404 matched non-statin treated patients with stable CAD. RESULTS: YKL-40 was significantly higher in non-statin treated 110 µg/l (median) compared with 65 µg/l in statin treated (p

Originalsprog	Engelsk
Tidsskrift	Inflammation Research
Vol/bind	60
Udgave nummer	3
Sider (fra-til)	281-7
Antal sider	7
ISSN	1023-3830
DOI	https://doi.org/10.1007/s00011-010-0266-5
Status	Udgivet - mar. 2011

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10.1007/s00011-010-0266-5

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title = "The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease",

abstract = "OBJECTIVE: The inflammatory biomarker YKL-40 is elevated and associated with mortality in patients with stable coronary artery disease (CAD). The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD. DESIGN: Serum YKL-40, HsCRP, total cholesterol, HDL-c, LDL-c and triglycerides levels were measured in 404 statin treated and in 404 matched non-statin treated patients with stable CAD. RESULTS: YKL-40 was significantly higher in non-statin treated 110 µg/l (median) compared with 65 µg/l in statin treated (p ",

author = "Mygind, {Naja Dam} and Harutyunyan, {Marina J} and Mathiasen, {Anders Bruun} and Ripa, {Rasmus Sejersten} and Thune, {Jens Jacob} and G{\o}tze, {Jens Peter} and Johansen, {Julia S} and Jens Kastrup and {The CLARICOR Trial Group}",

year = "2011",

month = mar,

doi = "10.1007/s00011-010-0266-5",

language = "English",

volume = "60",

pages = "281--7",

journal = "Inflammation Research",

issn = "1023-3830",

publisher = "Springer Basel AG",

number = "3",

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TY - JOUR

T1 - The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease

AU - Mygind, Naja Dam

AU - Harutyunyan, Marina J

AU - Mathiasen, Anders Bruun

AU - Ripa, Rasmus Sejersten

AU - Thune, Jens Jacob

AU - Gøtze, Jens Peter

AU - Johansen, Julia S

AU - Kastrup, Jens

AU - The CLARICOR Trial Group

PY - 2011/3

Y1 - 2011/3

N2 - OBJECTIVE: The inflammatory biomarker YKL-40 is elevated and associated with mortality in patients with stable coronary artery disease (CAD). The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD. DESIGN: Serum YKL-40, HsCRP, total cholesterol, HDL-c, LDL-c and triglycerides levels were measured in 404 statin treated and in 404 matched non-statin treated patients with stable CAD. RESULTS: YKL-40 was significantly higher in non-statin treated 110 µg/l (median) compared with 65 µg/l in statin treated (p

AB - OBJECTIVE: The inflammatory biomarker YKL-40 is elevated and associated with mortality in patients with stable coronary artery disease (CAD). The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD. DESIGN: Serum YKL-40, HsCRP, total cholesterol, HDL-c, LDL-c and triglycerides levels were measured in 404 statin treated and in 404 matched non-statin treated patients with stable CAD. RESULTS: YKL-40 was significantly higher in non-statin treated 110 µg/l (median) compared with 65 µg/l in statin treated (p

U2 - 10.1007/s00011-010-0266-5

DO - 10.1007/s00011-010-0266-5

M3 - Journal article

C2 - 20972697

SN - 1023-3830

VL - 60

SP - 281

EP - 287

JO - Inflammation Research

JF - Inflammation Research

IS - 3

ER -

The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease

Abstract

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