The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

Biochemistry, Genetics and Molecular Biology

• Protein Phosphorylation 100%
• Platelet 100%
• Thrombocyte Activation 60%
• Thrombin 40%
• Agonist 40%
• Nimodipine 40%
• Thrombocyte Aggregation 40%
• Myosin Light-Chain Kinase 20%
• Calcium Cell Level 20%
• Platelet-Rich Plasma 20%
• Calcium Transport 20%
• calcium activated,phospholipid dependent protein kinase 20%
• Cell Membrane 20%
• Dihydropyridine 20%
• Calcium Channel Blocker 20%
• Calcium Channel 20%
• Verapamil 20%
• Light Chain 20%
• Extracellular Calcium 20%
• Molecular Weight 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Thapsigargin 100%
• Neoplasm 100%
• Sesquiterpene Lactone 100%
• Calcimycin 40%
• Serotonin 30%
• Nimodipine 20%
• Thrombin 20%
• Diltiazem 10%
• Calcium Channel Blocker 10%
• Egtazic Acid 10%
• Phorbol Ester 10%
• 1,4 Dihydropyridine 10%
• Verapamil 10%
• Myosin Light Chain Kinase 10%
• calcium activated,phospholipid dependent protein kinase 10%

Keyphrases

• Serotonin Release 30%
• Diltiazem 10%
• Human Blood Platelets 10%
• Selective Phosphorylation 10%
• 1,4-Dihydropyridines (1,4-DHPs) 10%
• Intracellular Calcium Stores 10%
• Washed Platelets 10%