@article{bac5abd0fce511ddb219000ea68e967b,
title = "The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional",
abstract = "The role of quorum sensing in Pseudomonas aeruginosa biofilm formation is unclear. Some researchers have shown that quorum sensing is important for biofilm development, while others have indicated it has little or no role. In this study, the contribution of quorum sensing to biofilm development was found to depend upon the nutritional environment. Depending upon the carbon source, quorum-sensing mutant strains (lasIrhlI and lasRrhlR) either exhibited a pronounced defect early in biofilm formation or formed biofilms identical to the wild-type strain. Quorum sensing was then shown to exert its nutritionally conditional control of biofilm development through regulation of swarming motility. Examination of pilA and fliM mutant strains further supported the role of swarming motility in biofilm formation. These data led to a model proposing that the prevailing nutritional conditions dictate the contributions of quorum sensing and swarming motility at a key juncture early in biofilm development.",
author = "Shrout, {Joshua D} and Chopp, {David L} and Just, {Collin L} and Morten Hentzer and Michael Givskov and Parsek, {Matthew R}",
note = "Keywords: Biofilms; Food; Pseudomonas aeruginosa; Signal Transduction",
year = "2006",
doi = "10.1111/j.1365-2958.2006.05421.x",
language = "English",
volume = "62",
pages = "1264--77",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley-Blackwell",
number = "5",
}