@article{e87cda70e6f711ddbf70000ea68e967b,
title = "The impact of founder events on chromosomal variability in multiply mating species",
abstract = "In species with heterogametic males, the relative levels of X chromosome versus autosome diversity hold key information about the evolutionary forces at work in a population. It has been shown that population size changes alter the ratio of X linked to autosomal (X/A) variation, with population size reductions and recent bottlenecks leading to decreased X/A diversity ratios. Here we use theory and simulation to investigate a separate demographic effect-that of founder events involving multiply mated females-and find that it leads to much stronger reductions in X/A diversity ratios than are produced by simple population size changes. Investigating the potential of this process to account for sharply reduced X-linked diversity in European Drosophila melanogaster, we find that this model yields predictions that are compatible with the empirical data.",
author = "Pool, {John E} and Rasmus Nielsen",
note = "Keywords: Animals; Chromosomes; Computer Simulation; Drosophila melanogaster; Female; Founder Effect; Genes, X-Linked; Genetic Variation; Genetics, Population; Models, Genetic; Sexual Behavior, Animal",
year = "2008",
doi = "10.1093/molbev/msn124",
language = "English",
volume = "25",
pages = "1728--36",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "8",
}