TY - JOUR
T1 - The impact of CYP2D6 and CYP2C19 polymorphisms on suicidal behavior and substance abuse disorder among patients with schizophrenia: a retrospective study
AU - Kobylecki, C.J.
AU - Hansen, T.
AU - Timm, S.
AU - Wang, August Gabriel
AU - Jakobsen, K.D.
AU - Sørensen, Holger Jelling
AU - Rasmussen, Henrik Barner
AU - Werge, Thomas Mears
AU - Kobylecki, Camilla J
AU - Hansen, Thomas Folkmann
AU - Timm, Sally
AU - Wang, August
AU - Jakobsen, Klaus D
AU - Sørensen, Holger J
AU - Rasmussen, Henrik B
AU - Werge, Thomas
N1 - Keywords: Adult; Analysis of Variance; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Mixed Function Oxygenases; Odds Ratio; Patient Compliance; Phenotype; Polymorphism, Genetic; Retrospective Studies; Schizophrenia; Schizophrenic Psychology; Substance-Related Disorders; Suicide; Treatment Outcome
PY - 2008
Y1 - 2008
N2 - Suicidal behavior and substance abuse are frequent phenomena among patients with schizophrenia and may be attributable in part to antipsychotic treatment failure. Individuals who carry functional variants of the CYP2D6 and CYP2C19 genes, shown to cause altered drug metabolism of psychoactive drugs, are at risk of toxic accumulation or rapid elimination of these drugs, leading to treatment failure. We tested whether substance abuse disorder and suicidal behavior were associated with the CYP2D6 and CYP2C19 genotypes among patients with schizophrenia. Three hundred sixty-two patients with schizophrenia spectrum disorders (International Classification of Diseases, 10th Revision) were genotyped for functional CYP2D6 and CYP2C19 polymorphisms. Based on available medical records and clinical interviews, their suicidal behavior and substance abuse disorder were evaluated. No significant associations between the CYP2D6 and CYP2C19 genotypes and suicidal behavior or substance abuse disorder were noted, and we conclude that cytochrome P450 genotyping in its present form is clinically irrelevant with respect to these phenomena.
AB - Suicidal behavior and substance abuse are frequent phenomena among patients with schizophrenia and may be attributable in part to antipsychotic treatment failure. Individuals who carry functional variants of the CYP2D6 and CYP2C19 genes, shown to cause altered drug metabolism of psychoactive drugs, are at risk of toxic accumulation or rapid elimination of these drugs, leading to treatment failure. We tested whether substance abuse disorder and suicidal behavior were associated with the CYP2D6 and CYP2C19 genotypes among patients with schizophrenia. Three hundred sixty-two patients with schizophrenia spectrum disorders (International Classification of Diseases, 10th Revision) were genotyped for functional CYP2D6 and CYP2C19 polymorphisms. Based on available medical records and clinical interviews, their suicidal behavior and substance abuse disorder were evaluated. No significant associations between the CYP2D6 and CYP2C19 genotypes and suicidal behavior or substance abuse disorder were noted, and we conclude that cytochrome P450 genotyping in its present form is clinically irrelevant with respect to these phenomena.
U2 - http://dx.doi.org/10.1097/FTD.0b013e31817721d6
DO - http://dx.doi.org/10.1097/FTD.0b013e31817721d6
M3 - Journal article
SN - 0163-4356
VL - 30
SP - 265
EP - 270
JO - Therapeutic Drug Monitoring
JF - Therapeutic Drug Monitoring
IS - 3
ER -
