The human milk microbiota is modulated by maternal diet

Marina Padilha; Niels Banhos Danneskiold-Samsøe; Asker Brejnrod; Christian Hoffmann; Vanessa Pereira Cabral; Julia de Melo Iaucci; Cristiane Hermes Sales; Regina Mara Fisberg; Ramon Vitor Cortez; Susanne Brix; Carla Romano Taddei; Karsten Kristiansen; Susana Marta Isay Saad

doi:10.3390/microorganisms7110502

The human milk microbiota is modulated by maternal diet

Marina Padilha^*, Niels Banhos Danneskiold-Samsøe, Asker Brejnrod, Christian Hoffmann, Vanessa Pereira Cabral, Julia de Melo Iaucci, Cristiane Hermes Sales, Regina Mara Fisberg, Ramon Vitor Cortez, Susanne Brix, Carla Romano Taddei, Karsten Kristiansen, Susana Marta Isay Saad

^*Corresponding author af dette arbejde

18 Citationer (Scopus)

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Abstract

Human milk microorganisms contribute not only to the healthy development of the immune system in infants, but also in shaping the gut microbiota. We evaluated the effect of the maternal diet during pregnancy and during the first month of lactation on the human milk microbiota in a cross-sectional study including 94 healthy lactating women. Microbiota composition was determined by 16S rDNA profiling and nutrient intake assessed through food questionnaires. Thirteen genera were present in at least 90% of all samples, with three genera present in all samples: Streptococcus, Staphylococcus, and Corynebacterium. Cluster analysis indicated two distinct compositions: one marked by a high abundance of Streptococcus (cluster 1), and other by a high abundance of Staphylococcus (cluster 2). A global association with milk microbiota diversity was observed for vitamin C intake during pregnancy (p = 0.029), which was higher for cluster 2 individuals (cluster 2 median = 232 mg/d; cluster 1 = 175 mg/d; p = 0.02). Positive correlations were found between Bifidobacterium in the milk and intake of polyunsaturated and linoleic fatty acids during the lactation period (p < 0.01). We show that maternal diet influences the human milk microbiota, especially during pregnancy, which may contribute in shaping the gut microbiota.

Originalsprog	Engelsk
Artikelnummer	502
Tidsskrift	Microorganisms
Vol/bind	7
Udgave nummer	11
Antal sider	18
ISSN	2076-2607
DOI	https://doi.org/10.3390/microorganisms7110502
Status	Udgivet - 2019

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10.3390/microorganisms7110502Licens: CC BY

The human milk microbiota is modulated by maternal dietForlagets udgivne version, 1,16 MBLicens: CC BY

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title = "The human milk microbiota is modulated by maternal diet",

abstract = "Human milk microorganisms contribute not only to the healthy development of the immune system in infants, but also in shaping the gut microbiota. We evaluated the effect of the maternal diet during pregnancy and during the first month of lactation on the human milk microbiota in a cross-sectional study including 94 healthy lactating women. Microbiota composition was determined by 16S rDNA profiling and nutrient intake assessed through food questionnaires. Thirteen genera were present in at least 90% of all samples, with three genera present in all samples: Streptococcus, Staphylococcus, and Corynebacterium. Cluster analysis indicated two distinct compositions: one marked by a high abundance of Streptococcus (cluster 1), and other by a high abundance of Staphylococcus (cluster 2). A global association with milk microbiota diversity was observed for vitamin C intake during pregnancy (p = 0.029), which was higher for cluster 2 individuals (cluster 2 median = 232 mg/d; cluster 1 = 175 mg/d; p = 0.02). Positive correlations were found between Bifidobacterium in the milk and intake of polyunsaturated and linoleic fatty acids during the lactation period (p < 0.01). We show that maternal diet influences the human milk microbiota, especially during pregnancy, which may contribute in shaping the gut microbiota.",

keywords = "Breast milk, Breastfeeding, Gut colonization, Maternal diet, Microbiota",

author = "Marina Padilha and Danneskiold-Sams{\o}e, {Niels Banhos} and Asker Brejnrod and Christian Hoffmann and Cabral, {Vanessa Pereira} and Iaucci, {Julia de Melo} and Sales, {Cristiane Hermes} and Fisberg, {Regina Mara} and Cortez, {Ramon Vitor} and Susanne Brix and Taddei, {Carla Romano} and Karsten Kristiansen and Saad, {Susana Marta Isay}",

year = "2019",

doi = "10.3390/microorganisms7110502",

language = "English",

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TY - JOUR

T1 - The human milk microbiota is modulated by maternal diet

AU - Padilha, Marina

AU - Danneskiold-Samsøe, Niels Banhos

AU - Brejnrod, Asker

AU - Hoffmann, Christian

AU - Cabral, Vanessa Pereira

AU - Iaucci, Julia de Melo

AU - Sales, Cristiane Hermes

AU - Fisberg, Regina Mara

AU - Cortez, Ramon Vitor

AU - Brix, Susanne

AU - Taddei, Carla Romano

AU - Kristiansen, Karsten

AU - Saad, Susana Marta Isay

PY - 2019

Y1 - 2019

N2 - Human milk microorganisms contribute not only to the healthy development of the immune system in infants, but also in shaping the gut microbiota. We evaluated the effect of the maternal diet during pregnancy and during the first month of lactation on the human milk microbiota in a cross-sectional study including 94 healthy lactating women. Microbiota composition was determined by 16S rDNA profiling and nutrient intake assessed through food questionnaires. Thirteen genera were present in at least 90% of all samples, with three genera present in all samples: Streptococcus, Staphylococcus, and Corynebacterium. Cluster analysis indicated two distinct compositions: one marked by a high abundance of Streptococcus (cluster 1), and other by a high abundance of Staphylococcus (cluster 2). A global association with milk microbiota diversity was observed for vitamin C intake during pregnancy (p = 0.029), which was higher for cluster 2 individuals (cluster 2 median = 232 mg/d; cluster 1 = 175 mg/d; p = 0.02). Positive correlations were found between Bifidobacterium in the milk and intake of polyunsaturated and linoleic fatty acids during the lactation period (p < 0.01). We show that maternal diet influences the human milk microbiota, especially during pregnancy, which may contribute in shaping the gut microbiota.

AB - Human milk microorganisms contribute not only to the healthy development of the immune system in infants, but also in shaping the gut microbiota. We evaluated the effect of the maternal diet during pregnancy and during the first month of lactation on the human milk microbiota in a cross-sectional study including 94 healthy lactating women. Microbiota composition was determined by 16S rDNA profiling and nutrient intake assessed through food questionnaires. Thirteen genera were present in at least 90% of all samples, with three genera present in all samples: Streptococcus, Staphylococcus, and Corynebacterium. Cluster analysis indicated two distinct compositions: one marked by a high abundance of Streptococcus (cluster 1), and other by a high abundance of Staphylococcus (cluster 2). A global association with milk microbiota diversity was observed for vitamin C intake during pregnancy (p = 0.029), which was higher for cluster 2 individuals (cluster 2 median = 232 mg/d; cluster 1 = 175 mg/d; p = 0.02). Positive correlations were found between Bifidobacterium in the milk and intake of polyunsaturated and linoleic fatty acids during the lactation period (p < 0.01). We show that maternal diet influences the human milk microbiota, especially during pregnancy, which may contribute in shaping the gut microbiota.

KW - Breast milk

KW - Breastfeeding

KW - Gut colonization

KW - Maternal diet

KW - Microbiota

U2 - 10.3390/microorganisms7110502

DO - 10.3390/microorganisms7110502

M3 - Journal article

C2 - 31671720

AN - SCOPUS:85074386132

SN - 2076-2607

VL - 7

JO - Microorganisms

JF - Microorganisms

IS - 11

M1 - 502

ER -

The human milk microbiota is modulated by maternal diet

Abstract

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