The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

Morag H Stewart; Mareike Albert; Patrycja Sroczynska; V Adam Cruickshank; Yanping Guo; Derrick J Rossi; Kristian Helin; Tariq Enver

doi:10.1182/blood-2014-08-596734

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

Morag H Stewart, Mareike Albert, Patrycja Sroczynska, V Adam Cruickshank, Yanping Guo, Derrick J Rossi, Kristian Helin, Tariq Enver

25 Citationer (Scopus)

Abstract

Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.

Originalsprog	Engelsk
Tidsskrift	Blood
ISSN	0006-4971
DOI	https://doi.org/10.1182/blood-2014-08-596734
Status	Udgivet - 26 mar. 2015

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10.1182/blood-2014-08-596734

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title = "The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal",

abstract = "Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.",

author = "Stewart, {Morag H} and Mareike Albert and Patrycja Sroczynska and Cruickshank, {V Adam} and Yanping Guo and Rossi, {Derrick J} and Kristian Helin and Tariq Enver",

note = "Copyright {\textcopyright} 2015 American Society of Hematology.",

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doi = "10.1182/blood-2014-08-596734",

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T1 - The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

AU - Stewart, Morag H

AU - Albert, Mareike

AU - Sroczynska, Patrycja

AU - Cruickshank, V Adam

AU - Guo, Yanping

AU - Rossi, Derrick J

AU - Helin, Kristian

AU - Enver, Tariq

PY - 2015/3/26

Y1 - 2015/3/26

N2 - Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.

AB - Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.

U2 - 10.1182/blood-2014-08-596734

DO - 10.1182/blood-2014-08-596734

M3 - Journal article

C2 - 25655602

SN - 0006-4971

JO - Blood

JF - Blood

ER -

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

Abstract

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