The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

José Manuel Alfonso Moreira; Peter Scheipers; Poul Sørensen

doi:10.1186/1471-2407-3-30

The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

José Manuel Alfonso Moreira, Peter Scheipers, Poul Sørensen

119 Citationer (Scopus)

Abstract

Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.

Originalsprog	Engelsk
Tidsskrift	B M C Cancer
Vol/bind	3
Sider (fra-til)	30
ISSN	1471-2407
DOI	https://doi.org/10.1186/1471-2407-3-30
Status	Udgivet - 2003

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10.1186/1471-2407-3-30

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title = "The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses",

abstract = "Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.",

keywords = "Animals, Antigens, CD, Apoptosis, CD4-Positive T-Lymphocytes, Caspases, Enzyme Inhibitors, Female, Gene Expression Regulation, Histone Deacetylase Inhibitors, Hydroxamic Acids, Interleukin-2, Lymphocyte Activation, Mice, Mice, Inbred C57BL, NF-kappa B, Reactive Oxygen Species, Signal Transduction, Transcriptional Activation",

author = "Moreira, {Jos{\'e} Manuel Alfonso} and Peter Scheipers and Poul S{\o}rensen",

year = "2003",

doi = "10.1186/1471-2407-3-30",

language = "English",

volume = "3",

pages = "30",

journal = "B M C Cancer",

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TY - JOUR

T1 - The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

AU - Moreira, José Manuel Alfonso

AU - Scheipers, Peter

AU - Sørensen, Poul

PY - 2003

Y1 - 2003

N2 - Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.

AB - Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.

KW - Animals

KW - Antigens, CD

KW - Apoptosis

KW - CD4-Positive T-Lymphocytes

KW - Caspases

KW - Enzyme Inhibitors

KW - Female

KW - Gene Expression Regulation

KW - Histone Deacetylase Inhibitors

KW - Hydroxamic Acids

KW - Interleukin-2

KW - Lymphocyte Activation

KW - Mice

KW - Mice, Inbred C57BL

KW - NF-kappa B

KW - Reactive Oxygen Species

KW - Signal Transduction

KW - Transcriptional Activation

U2 - 10.1186/1471-2407-3-30

DO - 10.1186/1471-2407-3-30

M3 - Journal article

C2 - 14606959

SN - 1471-2407

VL - 3

SP - 30

JO - B M C Cancer

JF - B M C Cancer

ER -

The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

Abstract

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