@article{91c5cb7035a111df8ed1000ea68e967b,
title = "The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation",
abstract = "The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter-regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.",
author = "H Kolb and T Mandrup-Poulsen",
year = "2009",
doi = "10.1007/s00125-009-1573-7",
language = "English",
volume = "53",
pages = "10--20",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "1",
}
