The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

TY - JOUR

T1 - The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

AU - Stefan, N

AU - Vozarova, B

AU - Del Parigi, A

AU - Ossowski, V

AU - Thompson, D B

AU - Hanson, R L

AU - Ravussin, E

AU - Tataranni, P A

AU - de Courten, Barbora

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P

AB - Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P

KW - Adipocytes

KW - Adult

KW - Cell Size

KW - Energy Metabolism

KW - Female

KW - Genotype

KW - Homozygote

KW - Humans

KW - Indians, North American

KW - Lipid Metabolism

KW - Male

KW - Motor Activity

KW - Polymorphism, Genetic

KW - Receptors, Cell Surface

KW - Receptors, Leptin

U2 - 10.1038/sj.ijo.0802161

DO - 10.1038/sj.ijo.0802161

M3 - Journal article

C2 - 12461680

SN - 0307-0565

VL - 26

SP - 1629

EP - 1632

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 12

ER -