The genome of the social amoeba Dictyostelium discoideum.

L Eichinger; J A Pachebat; G Glöckner; M-A Rajandream; R Sucgang; M Berriman; J Song; R Olsen; K Szafranski; Q Xu; B Tunggal; S Kummerfeld; M Madera; B A Konfortov; F Rivero; A T Bankier; R Lehmann; N Hamlin; R Davies; P Gaudet; P Fey; K Pilcher; G Chen; D Saunders; E Sodergren; P Davis; A Kerhornou; X Nie; N Hall; C Anjard; L Hemphill; N Bason; P Farbrother; B Desany; E Just; T Morio; R Rost; C Churcher; J Cooper; S Haydock; N van Driessche; A Cronin; I Goodhead; D Muzny; T Mourier; A Pain; M Lu; D Harper; R Lindsay; H Hauser; K James; M Quiles; M Madan Babu; T Saito; C Buchrieser; A Wardroper; M Felder; M Thangavelu; D Johnson; A Knights; H Loulseged; K Mungall; K Oliver; C Price; M A Quail; H Urushihara; J Hernandez; E Rabbinowitsch; D Steffen; M Sanders; J Ma; Y Kohara; S Sharp; M Simmonds; S Spiegler; A Tivey; S Sugano; B White; D Walker; J Woodward; T Winckler; Y Tanaka; G Shaulsky; M Schleicher; G Weinstock; A Rosenthal; E C Cox; R L Chisholm; R Gibbs; W F Loomis; M Platzer; R R Kay; J Williams; P H Dear; A A Noegel; B Barrell; A Kuspa

doi:10.1038/nature03481

The genome of the social amoeba Dictyostelium discoideum.

L Eichinger, J A Pachebat, G Glöckner, M-A Rajandream, R Sucgang, M Berriman, J Song, R Olsen, K Szafranski, Q Xu, B Tunggal, S Kummerfeld, M Madera, B A Konfortov, F Rivero, A T Bankier, R Lehmann, N Hamlin, R Davies, P GaudetP Fey, K Pilcher, G Chen, D Saunders, E Sodergren, P Davis, A Kerhornou, X Nie, N Hall, C Anjard, L Hemphill, N Bason, P Farbrother, B Desany, E Just, T Morio, R Rost, C Churcher, J Cooper, S Haydock, N van Driessche, A Cronin, I Goodhead, D Muzny, T Mourier, A Pain, M Lu, D Harper, R Lindsay, H Hauser, K James, M Quiles, M Madan Babu, T Saito, C Buchrieser, A Wardroper, M Felder, M Thangavelu, D Johnson, A Knights, H Loulseged, K Mungall, K Oliver, C Price, M A Quail, H Urushihara, J Hernandez, E Rabbinowitsch, D Steffen, M Sanders, J Ma, Y Kohara, S Sharp, M Simmonds, S Spiegler, A Tivey, S Sugano, B White, D Walker, J Woodward, T Winckler, Y Tanaka, G Shaulsky, M Schleicher, G Weinstock, A Rosenthal, E C Cox, R L Chisholm, R Gibbs, W F Loomis, M Platzer, R R Kay, J Williams, P H Dear, A A Noegel, B Barrell, A Kuspa

Microbiology

902 Citationer (Scopus)

Abstract

Udgivelsesdato: 2005-May-5

Originalsprog	Engelsk
Tidsskrift	Nature
Vol/bind	435
Udgave nummer	7038
Sider (fra-til)	43-57
Antal sider	14
ISSN	0028-0836
DOI	https://doi.org/10.1038/nature03481
Status	Udgivet - 2005

Adgang til dokumentet

10.1038/nature03481

Citationsformater

Eichinger, L., Pachebat, J. A., Glöckner, G., Rajandream, M-A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, Q., Tunggal, B., Kummerfeld, S., Madera, M., Konfortov, B. A., Rivero, F., Bankier, A. T., Lehmann, R., Hamlin, N., Davies, R., ... Kuspa, A. (2005). The genome of the social amoeba Dictyostelium discoideum. Nature, 435(7038), 43-57. https://doi.org/10.1038/nature03481

Eichinger, L, Pachebat, JA, Glöckner, G, Rajandream, M-A, Sucgang, R, Berriman, M, Song, J, Olsen, R, Szafranski, K, Xu, Q, Tunggal, B, Kummerfeld, S, Madera, M, Konfortov, BA, Rivero, F, Bankier, AT, Lehmann, R, Hamlin, N, Davies, R, Gaudet, P, Fey, P, Pilcher, K, Chen, G, Saunders, D, Sodergren, E, Davis, P, Kerhornou, A, Nie, X, Hall, N, Anjard, C, Hemphill, L, Bason, N, Farbrother, P, Desany, B, Just, E, Morio, T, Rost, R, Churcher, C, Cooper, J, Haydock, S, van Driessche, N, Cronin, A, Goodhead, I, Muzny, D, Mourier, T, Pain, A, Lu, M, Harper, D, Lindsay, R, Hauser, H, James, K, Quiles, M, Madan Babu, M, Saito, T, Buchrieser, C, Wardroper, A, Felder, M, Thangavelu, M, Johnson, D, Knights, A, Loulseged, H, Mungall, K, Oliver, K, Price, C, Quail, MA, Urushihara, H, Hernandez, J, Rabbinowitsch, E, Steffen, D, Sanders, M, Ma, J, Kohara, Y, Sharp, S, Simmonds, M, Spiegler, S, Tivey, A, Sugano, S, White, B, Walker, D, Woodward, J, Winckler, T, Tanaka, Y, Shaulsky, G, Schleicher, M, Weinstock, G, Rosenthal, A, Cox, EC, Chisholm, RL, Gibbs, R, Loomis, WF, Platzer, M, Kay, RR, Williams, J, Dear, PH, Noegel, AA, Barrell, B & Kuspa, A 2005, 'The genome of the social amoeba Dictyostelium discoideum.', Nature, bind 435, nr. 7038, s. 43-57. https://doi.org/10.1038/nature03481

@article{3013eb00e39b11dcbee902004c4f4f50,

title = "The genome of the social amoeba Dictyostelium discoideum.",

abstract = "The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium discoideum. The gene-dense chromosomes of this organism encode approximately 12,500 predicted proteins, a high proportion of which have long, repetitive amino acid tracts. There are many genes for polyketide synthases and ABC transporters, suggesting an extensive secondary metabolism for producing and exporting small molecules. The genome is rich in complex repeats, one class of which is clustered and may serve as centromeres. Partial copies of the extrachromosomal ribosomal DNA (rDNA) element are found at the ends of each chromosome, suggesting a novel telomere structure and the use of a common mechanism to maintain both the rDNA and chromosomal termini. A proteome-based phylogeny shows that the amoebozoa diverged from the animal-fungal lineage after the plant-animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.",

author = "L Eichinger and Pachebat, {J A} and G Gl{\"o}ckner and M-A Rajandream and R Sucgang and M Berriman and J Song and R Olsen and K Szafranski and Q Xu and B Tunggal and S Kummerfeld and M Madera and Konfortov, {B A} and F Rivero and Bankier, {A T} and R Lehmann and N Hamlin and R Davies and P Gaudet and P Fey and K Pilcher and G Chen and D Saunders and E Sodergren and P Davis and A Kerhornou and X Nie and N Hall and C Anjard and L Hemphill and N Bason and P Farbrother and B Desany and E Just and T Morio and R Rost and C Churcher and J Cooper and S Haydock and {van Driessche}, N and A Cronin and I Goodhead and D Muzny and T Mourier and A Pain and M Lu and D Harper and R Lindsay and H Hauser and K James and M Quiles and {Madan Babu}, M and T Saito and C Buchrieser and A Wardroper and M Felder and M Thangavelu and D Johnson and A Knights and H Loulseged and K Mungall and K Oliver and C Price and Quail, {M A} and H Urushihara and J Hernandez and E Rabbinowitsch and D Steffen and M Sanders and J Ma and Y Kohara and S Sharp and M Simmonds and S Spiegler and A Tivey and S Sugano and B White and D Walker and J Woodward and T Winckler and Y Tanaka and G Shaulsky and M Schleicher and G Weinstock and A Rosenthal and Cox, {E C} and Chisholm, {R L} and R Gibbs and Loomis, {W F} and M Platzer and Kay, {R R} and J Williams and Dear, {P H} and Noegel, {A A} and B Barrell and A Kuspa",

note = "Keywords: ATP-Binding Cassette Transporters; Animals; Base Composition; Cell Adhesion; Cell Movement; Centromere; Conserved Sequence; DNA Transposable Elements; DNA, Ribosomal; Dictyostelium; Eukaryotic Cells; Gene Duplication; Gene Transfer, Horizontal; Genome; Genomics; Humans; Molecular Sequence Data; Phylogeny; Proteome; Protozoan Proteins; RNA, Transfer; Repetitive Sequences, Nucleic Acid; Sequence Analysis, DNA; Signal Transduction; Social Behavior; Telomere",

year = "2005",

doi = "10.1038/nature03481",

language = "English",

volume = "435",

pages = "43--57",

journal = "Nature",

issn = "0028-0836",

publisher = "nature publishing group",

number = "7038",

}

TY - JOUR

T1 - The genome of the social amoeba Dictyostelium discoideum.

AU - Eichinger, L

AU - Pachebat, J A

AU - Glöckner, G

AU - Rajandream, M-A

AU - Sucgang, R

AU - Berriman, M

AU - Song, J

AU - Olsen, R

AU - Szafranski, K

AU - Xu, Q

AU - Tunggal, B

AU - Kummerfeld, S

AU - Madera, M

AU - Konfortov, B A

AU - Rivero, F

AU - Bankier, A T

AU - Lehmann, R

AU - Hamlin, N

AU - Davies, R

AU - Gaudet, P

AU - Fey, P

AU - Pilcher, K

AU - Chen, G

AU - Saunders, D

AU - Sodergren, E

AU - Davis, P

AU - Kerhornou, A

AU - Nie, X

AU - Hall, N

AU - Anjard, C

AU - Hemphill, L

AU - Bason, N

AU - Farbrother, P

AU - Desany, B

AU - Just, E

AU - Morio, T

AU - Rost, R

AU - Churcher, C

AU - Cooper, J

AU - Haydock, S

AU - van Driessche, N

AU - Cronin, A

AU - Goodhead, I

AU - Muzny, D

AU - Mourier, T

AU - Pain, A

AU - Lu, M

AU - Harper, D

AU - Lindsay, R

AU - Hauser, H

AU - James, K

AU - Quiles, M

AU - Madan Babu, M

AU - Saito, T

AU - Buchrieser, C

AU - Wardroper, A

AU - Felder, M

AU - Thangavelu, M

AU - Johnson, D

AU - Knights, A

AU - Loulseged, H

AU - Mungall, K

AU - Oliver, K

AU - Price, C

AU - Quail, M A

AU - Urushihara, H

AU - Hernandez, J

AU - Rabbinowitsch, E

AU - Steffen, D

AU - Sanders, M

AU - Ma, J

AU - Kohara, Y

AU - Sharp, S

AU - Simmonds, M

AU - Spiegler, S

AU - Tivey, A

AU - Sugano, S

AU - White, B

AU - Walker, D

AU - Woodward, J

AU - Winckler, T

AU - Tanaka, Y

AU - Shaulsky, G

AU - Schleicher, M

AU - Weinstock, G

AU - Rosenthal, A

AU - Cox, E C

AU - Chisholm, R L

AU - Gibbs, R

AU - Loomis, W F

AU - Platzer, M

AU - Kay, R R

AU - Williams, J

AU - Dear, P H

AU - Noegel, A A

AU - Barrell, B

AU - Kuspa, A

N1 - Keywords: ATP-Binding Cassette Transporters; Animals; Base Composition; Cell Adhesion; Cell Movement; Centromere; Conserved Sequence; DNA Transposable Elements; DNA, Ribosomal; Dictyostelium; Eukaryotic Cells; Gene Duplication; Gene Transfer, Horizontal; Genome; Genomics; Humans; Molecular Sequence Data; Phylogeny; Proteome; Protozoan Proteins; RNA, Transfer; Repetitive Sequences, Nucleic Acid; Sequence Analysis, DNA; Signal Transduction; Social Behavior; Telomere

PY - 2005

Y1 - 2005

N2 - The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium discoideum. The gene-dense chromosomes of this organism encode approximately 12,500 predicted proteins, a high proportion of which have long, repetitive amino acid tracts. There are many genes for polyketide synthases and ABC transporters, suggesting an extensive secondary metabolism for producing and exporting small molecules. The genome is rich in complex repeats, one class of which is clustered and may serve as centromeres. Partial copies of the extrachromosomal ribosomal DNA (rDNA) element are found at the ends of each chromosome, suggesting a novel telomere structure and the use of a common mechanism to maintain both the rDNA and chromosomal termini. A proteome-based phylogeny shows that the amoebozoa diverged from the animal-fungal lineage after the plant-animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.

AB - The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium discoideum. The gene-dense chromosomes of this organism encode approximately 12,500 predicted proteins, a high proportion of which have long, repetitive amino acid tracts. There are many genes for polyketide synthases and ABC transporters, suggesting an extensive secondary metabolism for producing and exporting small molecules. The genome is rich in complex repeats, one class of which is clustered and may serve as centromeres. Partial copies of the extrachromosomal ribosomal DNA (rDNA) element are found at the ends of each chromosome, suggesting a novel telomere structure and the use of a common mechanism to maintain both the rDNA and chromosomal termini. A proteome-based phylogeny shows that the amoebozoa diverged from the animal-fungal lineage after the plant-animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.

U2 - 10.1038/nature03481

DO - 10.1038/nature03481

M3 - Journal article

C2 - 15875012

SN - 0028-0836

VL - 435

SP - 43

EP - 57

JO - Nature

JF - Nature

IS - 7038

ER -

The genome of the social amoeba Dictyostelium discoideum.

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater