The genealogy, site frequency spectrum and ages of two nested mutant alleles

TY - JOUR

T1 - The genealogy, site frequency spectrum and ages of two nested mutant alleles

AU - Hobolth, Asger

AU - Wiuf, Carsten

PY - 2009/6/1

Y1 - 2009/6/1

N2 - In this paper we consider the genealogy of two nested mutant alleles, assuming the constant-size neutral coalescent model with infinite sites mutation. We study the conditional genealogy and derive explicit formulas for the joint and marginal site frequency spectra for the double, single and zero mutant allele. In addition, we find the mean ages of the two mutations. We show that the age of the youngest mutation does not depend on the frequency of the single mutant allele and that the frequency spectra for the single mutant allele and the zero mutant allele are the same.

AB - In this paper we consider the genealogy of two nested mutant alleles, assuming the constant-size neutral coalescent model with infinite sites mutation. We study the conditional genealogy and derive explicit formulas for the joint and marginal site frequency spectra for the double, single and zero mutant allele. In addition, we find the mean ages of the two mutations. We show that the age of the youngest mutation does not depend on the frequency of the single mutant allele and that the frequency spectra for the single mutant allele and the zero mutant allele are the same.

KW - Age of a mutation

KW - Coalescent

KW - Genealogy

KW - Jump chain

KW - Nested mutations

UR - http://www.scopus.com/inward/record.url?scp=67349269539&partnerID=8YFLogxK

U2 - 10.1016/j.tpb.2009.02.001

DO - 10.1016/j.tpb.2009.02.001

M3 - Journal article

C2 - 19249321

AN - SCOPUS:67349269539

SN - 0040-5809

VL - 75

SP - 260

EP - 265

JO - Theoretical Population Biology

JF - Theoretical Population Biology

IS - 4

ER -