The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites

TY - JOUR

T1 - The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites

AU - Jensen, Dorit P

AU - Andersen, Mette K

AU - Hansen, Lars

AU - Eiberg, Hans

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Andreasen, Camilla H

PY - 2007

Y1 - 2007

N2 - Food intake and weight gain are influenced by endocannabinoids whose actions are regulated by the fatty acid amide hydrolase (FAAH) enzyme. The homozygous Thr/Thr genotype of the functional Pro129Thr variant (rs324420) in the gene encoding FAAH was recently reported to associate with overweight and obesity in white and black populations. We investigated the Pro129Thr variant in relation to overweight and obesity in a relatively large population-based study sample of Danish whites (n=5,801). In case-control studies of obesity, a borderline association with the major Pro allele was identified; however, after correction for multiple testing, no association was found. Furthermore, a possible association between the major Pro allele and obesity was not supported by studies of obesity-related quantitative traits. In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites.

AB - Food intake and weight gain are influenced by endocannabinoids whose actions are regulated by the fatty acid amide hydrolase (FAAH) enzyme. The homozygous Thr/Thr genotype of the functional Pro129Thr variant (rs324420) in the gene encoding FAAH was recently reported to associate with overweight and obesity in white and black populations. We investigated the Pro129Thr variant in relation to overweight and obesity in a relatively large population-based study sample of Danish whites (n=5,801). In case-control studies of obesity, a borderline association with the major Pro allele was identified; however, after correction for multiple testing, no association was found. Furthermore, a possible association between the major Pro allele and obesity was not supported by studies of obesity-related quantitative traits. In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites.

KW - Adult

KW - Amidohydrolases

KW - Body Mass Index

KW - Case-Control Studies

KW - Cohort Studies

KW - Denmark

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutation

KW - Obesity

KW - Phenotype

KW - Population Surveillance

KW - Proline

KW - Threonine

U2 - 10.1007/s00109-006-0139-0

DO - 10.1007/s00109-006-0139-0

M3 - Journal article

C2 - 17216208

SN - 0946-2716

VL - 85

SP - 445

EP - 449

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

IS - 5

ER -