The expansion behaviour of sea anemones may be coordinated by two inhibitory neuropeptides, Antho-KAamide and Antho-RIamide

TY - JOUR

T1 - The expansion behaviour of sea anemones may be coordinated by two inhibitory neuropeptides, Antho-KAamide and Antho-RIamide

AU - McFarlane, I D

AU - Hudman, D

AU - Nothacker, H P

AU - Grimmelikhuijzen, C J

PY - 1993/8/23

Y1 - 1993/8/23

N2 - Antho-KAamide (L-3-phenyllactyl-Phe-Lys-Ala-NH2) and Antho-RIamide (L-3-phenyllactyl-Tyr-Arg-Ile-NH2) are novel neuropeptides isolated from the sea anemone Anthopleura elegantissima. They both inhibited spontaneous contractions of isolated muscle preparations from a wide variety of anemone species (threshold around 10(-7) M). Their actions were universal in that they inhibited every muscle preparation tested, regardless of whether the muscle group was located in the ectoderm or endoderm, or was oriented in a circular or longitudinal direction. Injection of Antho-KAamide or Antho-RIamide into the coelenteron of intact sea anemones resulted in a marked expansion of the animals. Similar shape changes followed feeding or exposure to soluble food extracts. Therefore, we hypothesize that nerve cells that release Antho-KAamide and Antho-RIamide are involved in the expansion phase of feeding behaviour in sea anemones.

AB - Antho-KAamide (L-3-phenyllactyl-Phe-Lys-Ala-NH2) and Antho-RIamide (L-3-phenyllactyl-Tyr-Arg-Ile-NH2) are novel neuropeptides isolated from the sea anemone Anthopleura elegantissima. They both inhibited spontaneous contractions of isolated muscle preparations from a wide variety of anemone species (threshold around 10(-7) M). Their actions were universal in that they inhibited every muscle preparation tested, regardless of whether the muscle group was located in the ectoderm or endoderm, or was oriented in a circular or longitudinal direction. Injection of Antho-KAamide or Antho-RIamide into the coelenteron of intact sea anemones resulted in a marked expansion of the animals. Similar shape changes followed feeding or exposure to soluble food extracts. Therefore, we hypothesize that nerve cells that release Antho-KAamide and Antho-RIamide are involved in the expansion phase of feeding behaviour in sea anemones.

KW - Animals

KW - Electric Stimulation

KW - Muscle Contraction

KW - Muscles

KW - Neuropeptides

KW - Oligopeptides

KW - Sea Anemones

KW - Species Specificity

U2 - 10.1098/rspb.1993.0100

DO - 10.1098/rspb.1993.0100

M3 - Journal article

C2 - 8397415

SN - 0962-8452

VL - 253

SP - 183

EP - 188

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

IS - 1337

ER -