The energetic brain - A review from students to students

M P Bordone; M M Salman; H E Titus; E Amini; J V Andersen; B Chakraborti; A V Diuba; T G Dubouskaya; E Ehrke; A E Freitas; G B Freitas; R A Gonçalves; D Gupta; S R Ha; I A Hemming; M Jaggar; E Jakobsen; P Kumari; N Lakkappa; A P L Marsh; J Mitlöhner; Y Ogawa; R K Paidi; F C Ribeiro; A Salamian; S Saleem; S Sharma; J M Silva; K Sulakhiya; T W Tefera; B Vafadari; A Yadav; R Yamazaki; C I Seidenbecher

doi:10.1111/jnc.14829

The energetic brain - A review from students to students

M P Bordone, M M Salman, H E Titus, E Amini, J V Andersen, B Chakraborti, A V Diuba, T G Dubouskaya, E Ehrke, A E Freitas, G B Freitas, R A Gonçalves, D Gupta, S R Ha, I A Hemming, M Jaggar, E Jakobsen, P Kumari, N Lakkappa, A P L MarshJ Mitlöhner, Y Ogawa, R K Paidi, F C Ribeiro, A Salamian, S Saleem, S Sharma, J M Silva, K Sulakhiya, T W Tefera, B Vafadari, A Yadav, R Yamazaki, C I Seidenbecher

48 Citationer (Scopus)

Abstract

The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate brain has a high need for energy because of the high number of neurons and the need to maintain a delicate interplay between energy metabolism, neurotransmission, and plasticity. Disturbances to the energetic balance, to mitochondria quality control or to glia–neuron metabolic interaction may lead to brain circuit malfunction or even severe disorders of the CNS. We cover neuronal energy consumption in neural transmission and basic (‘housekeeping’) cellular processes. Additionally, we describe the most common (glucose) and alternative sources of energy namely glutamate, lactate, ketone bodies, and medium chain fatty acids. We discuss the multifaceted role of non-neuronal cells in the transport of energy substrates from circulation (pericytes and astrocytes) and in the supply (astrocytes and microglia) and usage of different energy fuels. Finally, we address pathological consequences of disrupted energy homeostasis in the CNS. (Figure presented.).

Originalsprog	Engelsk
Tidsskrift	Journal of Neurochemistry
ISSN	0022-3042
DOI	https://doi.org/10.1111/jnc.14829
Status	Udgivet - 1 okt. 2019

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10.1111/jnc.14829Licens: CC BY-NC-ND

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Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Freitas, A. E., Freitas, G. B., Gonçalves, R. A., Gupta, D., Ha, S. R., Hemming, I. A., Jaggar, M., Jakobsen, E., Kumari, P., Lakkappa, N., ... Seidenbecher, C. I. (2019). The energetic brain - A review from students to students. Journal of Neurochemistry. https://doi.org/10.1111/jnc.14829

Bordone, MP, Salman, MM, Titus, HE, Amini, E, Andersen, JV, Chakraborti, B, Diuba, AV, Dubouskaya, TG, Ehrke, E, Freitas, AE, Freitas, GB, Gonçalves, RA, Gupta, D, Ha, SR, Hemming, IA, Jaggar, M, Jakobsen, E, Kumari, P, Lakkappa, N, L Marsh, AP, Mitlöhner, J, Ogawa, Y, Paidi, RK, Ribeiro, FC, Salamian, A, Saleem, S, Sharma, S, Silva, JM, Sulakhiya, K, Tefera, TW, Vafadari, B, Yadav, A, Yamazaki, R & Seidenbecher, CI 2019, 'The energetic brain - A review from students to students', Journal of Neurochemistry. https://doi.org/10.1111/jnc.14829

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title = "The energetic brain - A review from students to students",

abstract = "The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate brain has a high need for energy because of the high number of neurons and the need to maintain a delicate interplay between energy metabolism, neurotransmission, and plasticity. Disturbances to the energetic balance, to mitochondria quality control or to glia–neuron metabolic interaction may lead to brain circuit malfunction or even severe disorders of the CNS. We cover neuronal energy consumption in neural transmission and basic ({\textquoteleft}housekeeping{\textquoteright}) cellular processes. Additionally, we describe the most common (glucose) and alternative sources of energy namely glutamate, lactate, ketone bodies, and medium chain fatty acids. We discuss the multifaceted role of non-neuronal cells in the transport of energy substrates from circulation (pericytes and astrocytes) and in the supply (astrocytes and microglia) and usage of different energy fuels. Finally, we address pathological consequences of disrupted energy homeostasis in the CNS. (Figure presented.).",

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AU - Bordone, M P

AU - Salman, M M

AU - Titus, H E

AU - Amini, E

AU - Andersen, J V

AU - Chakraborti, B

AU - Diuba, A V

AU - Dubouskaya, T G

AU - Ehrke, E

AU - Freitas, A E

AU - Freitas, G B

AU - Gonçalves, R A

AU - Gupta, D

AU - Ha, S R

AU - Hemming, I A

AU - Jaggar, M

AU - Jakobsen, E

AU - Kumari, P

AU - Lakkappa, N

AU - L Marsh, A P

AU - Mitlöhner, J

AU - Ogawa, Y

AU - Paidi, R K

AU - Ribeiro, F C

AU - Salamian, A

AU - Saleem, S

AU - Sharma, S

AU - Silva, J M

AU - Sulakhiya, K

AU - Tefera, T W

AU - Vafadari, B

AU - Yadav, A

AU - Yamazaki, R

AU - Seidenbecher, C I

PY - 2019/10/1

Y1 - 2019/10/1

N2 - The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate brain has a high need for energy because of the high number of neurons and the need to maintain a delicate interplay between energy metabolism, neurotransmission, and plasticity. Disturbances to the energetic balance, to mitochondria quality control or to glia–neuron metabolic interaction may lead to brain circuit malfunction or even severe disorders of the CNS. We cover neuronal energy consumption in neural transmission and basic (‘housekeeping’) cellular processes. Additionally, we describe the most common (glucose) and alternative sources of energy namely glutamate, lactate, ketone bodies, and medium chain fatty acids. We discuss the multifaceted role of non-neuronal cells in the transport of energy substrates from circulation (pericytes and astrocytes) and in the supply (astrocytes and microglia) and usage of different energy fuels. Finally, we address pathological consequences of disrupted energy homeostasis in the CNS. (Figure presented.).

AB - The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate brain has a high need for energy because of the high number of neurons and the need to maintain a delicate interplay between energy metabolism, neurotransmission, and plasticity. Disturbances to the energetic balance, to mitochondria quality control or to glia–neuron metabolic interaction may lead to brain circuit malfunction or even severe disorders of the CNS. We cover neuronal energy consumption in neural transmission and basic (‘housekeeping’) cellular processes. Additionally, we describe the most common (glucose) and alternative sources of energy namely glutamate, lactate, ketone bodies, and medium chain fatty acids. We discuss the multifaceted role of non-neuronal cells in the transport of energy substrates from circulation (pericytes and astrocytes) and in the supply (astrocytes and microglia) and usage of different energy fuels. Finally, we address pathological consequences of disrupted energy homeostasis in the CNS. (Figure presented.).

U2 - 10.1111/jnc.14829

DO - 10.1111/jnc.14829

M3 - Review

C2 - 31318452

SN - 0022-3042

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

ER -

The energetic brain - A review from students to students

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