The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention

Anne Lundby Hess; Alfonso Benítez-Páez; Trine Blædel; Lesli Hingstrup Larsen; Jose Ramón Iglesias; Carmen Madera; Yolanda Sanz; Thomas Meinert Larsen; MyNewGut Consortium

doi:10.1007/s00394-019-02099-x

The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention

Anne Lundby Hess^*, Alfonso Benítez-Páez, Trine Blædel, Lesli Hingstrup Larsen, Jose Ramón Iglesias, Carmen Madera, Yolanda Sanz, Thomas Meinert Larsen, MyNewGut Consortium

^*Corresponding author af dette arbejde

Institut for Idræt og Ernæring - Fedmeforskning

6 Citationer (Scopus)

Abstract

Purpose: The objective of this study was to investigate the additive effects of combining energy restriction with dietary fibres on change in body weight and gut microbiota composition.

Methods: The study was a 12-week randomised, placebo-controlled, double-blinded, parallel intervention trial. A total of 116 overweight or obese participants were assigned randomly either to 10 g inulin plus 10 g resistant maltodextrin or to 20 g of placebo supplementation through 400 mL of milk a day, while on a - 500 kcal/day energy restricted diet.

Results: Altogether, 86 participants completed the intervention. There were no significant differences in weight loss or body composition between the groups. The fibre supplement reduced systolic (5.35 ± 2.4 mmHg, p = 0.043) and diastolic (2.82 ± 1.3 mmHg, p = 0.047) blood pressure to a larger extent than placebo. Furthermore, a larger decrease in serum insulin was observed in the placebo group compared to the fibre group (- 26.0 ± 9.2 pmol/L, p = 0.006). The intake of fibre induced changes in the composition of gut microbiota resulting in higher abundances of Parabacteroides and Bifidobacteria, compared to placebo. The effects on blood pressure and glucose metabolism were mainly observed in women, and could be attributed to a higher gut microbiota diversity after intervention. Finally, the fibre group experienced a higher degree of gastrointestinal symptoms, which attenuated over time.

Conclusions: Supplementation of inulin and resistant maltodextrin did not provide an additional weight loss during an energy-restricted diet, but reduced both systolic and diastolic blood pressure. Furthermore, the fibre supplement did stimulate the growth of potentially beneficial bacteria genera.

Clinical trial registry: The study was registered at http://www.clinicaltrials.gov , NCT03135041.

Originalsprog	Engelsk
Tidsskrift	European Journal of Nutrition
ISSN	1436-6207
DOI	https://doi.org/10.1007/s00394-019-02099-x
Status	Udgivet - 1 sep. 2020

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Det Natur- og Biovidenskabelige Fakultet

FN’s Verdensmål

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10.1007/s00394-019-02099-x

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Hess, A. L., Benítez-Páez, A., Blædel, T., Larsen, L. H., Iglesias, J. R., Madera, C., Sanz, Y., Larsen, T. M., & MyNewGut Consortium (2020). The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention. European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02099-x

@article{46bd4ab3d3874a39b4787a157330155a,

title = "The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention",

abstract = "Purpose: The objective of this study was to investigate the additive effects of combining energy restriction with dietary fibres on change in body weight and gut microbiota composition.Methods: The study was a 12-week randomised, placebo-controlled, double-blinded, parallel intervention trial. A total of 116 overweight or obese participants were assigned randomly either to 10 g inulin plus 10 g resistant maltodextrin or to 20 g of placebo supplementation through 400 mL of milk a day, while on a - 500 kcal/day energy restricted diet.Results: Altogether, 86 participants completed the intervention. There were no significant differences in weight loss or body composition between the groups. The fibre supplement reduced systolic (5.35 ± 2.4 mmHg, p = 0.043) and diastolic (2.82 ± 1.3 mmHg, p = 0.047) blood pressure to a larger extent than placebo. Furthermore, a larger decrease in serum insulin was observed in the placebo group compared to the fibre group (- 26.0 ± 9.2 pmol/L, p = 0.006). The intake of fibre induced changes in the composition of gut microbiota resulting in higher abundances of Parabacteroides and Bifidobacteria, compared to placebo. The effects on blood pressure and glucose metabolism were mainly observed in women, and could be attributed to a higher gut microbiota diversity after intervention. Finally, the fibre group experienced a higher degree of gastrointestinal symptoms, which attenuated over time.Conclusions: Supplementation of inulin and resistant maltodextrin did not provide an additional weight loss during an energy-restricted diet, but reduced both systolic and diastolic blood pressure. Furthermore, the fibre supplement did stimulate the growth of potentially beneficial bacteria genera.Clinical trial registry: The study was registered at http://www.clinicaltrials.gov , NCT03135041.",

keywords = "Faculty of Science, Dietary fibre, Gut microbiome, Inulin, Maltodextrin, Obesity, Weight loss",

author = "Hess, {Anne Lundby} and Alfonso Ben{\'i}tez-P{\'a}ez and Trine Bl{\ae}del and Larsen, {Lesli Hingstrup} and Iglesias, {Jose Ram{\'o}n} and Carmen Madera and Yolanda Sanz and Larsen, {Thomas Meinert} and {MyNewGut Consortium}",

note = "CURIS 2019 NEXS 333",

year = "2020",

month = sep,

day = "1",

doi = "10.1007/s00394-019-02099-x",

language = "English",

journal = "European Journal of Nutrition",

issn = "1436-6207",

publisher = "Springer Medizin",

}

TY - JOUR

T1 - The effect of inulin and resistant maltodextrin on weight loss during energy restriction

T2 - a randomised, placebo-controlled, double-blinded intervention

AU - Hess, Anne Lundby

AU - Benítez-Páez, Alfonso

AU - Blædel, Trine

AU - Larsen, Lesli Hingstrup

AU - Iglesias, Jose Ramón

AU - Madera, Carmen

AU - Sanz, Yolanda

AU - Larsen, Thomas Meinert

AU - MyNewGut Consortium

N1 - CURIS 2019 NEXS 333

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Purpose: The objective of this study was to investigate the additive effects of combining energy restriction with dietary fibres on change in body weight and gut microbiota composition.Methods: The study was a 12-week randomised, placebo-controlled, double-blinded, parallel intervention trial. A total of 116 overweight or obese participants were assigned randomly either to 10 g inulin plus 10 g resistant maltodextrin or to 20 g of placebo supplementation through 400 mL of milk a day, while on a - 500 kcal/day energy restricted diet.Results: Altogether, 86 participants completed the intervention. There were no significant differences in weight loss or body composition between the groups. The fibre supplement reduced systolic (5.35 ± 2.4 mmHg, p = 0.043) and diastolic (2.82 ± 1.3 mmHg, p = 0.047) blood pressure to a larger extent than placebo. Furthermore, a larger decrease in serum insulin was observed in the placebo group compared to the fibre group (- 26.0 ± 9.2 pmol/L, p = 0.006). The intake of fibre induced changes in the composition of gut microbiota resulting in higher abundances of Parabacteroides and Bifidobacteria, compared to placebo. The effects on blood pressure and glucose metabolism were mainly observed in women, and could be attributed to a higher gut microbiota diversity after intervention. Finally, the fibre group experienced a higher degree of gastrointestinal symptoms, which attenuated over time.Conclusions: Supplementation of inulin and resistant maltodextrin did not provide an additional weight loss during an energy-restricted diet, but reduced both systolic and diastolic blood pressure. Furthermore, the fibre supplement did stimulate the growth of potentially beneficial bacteria genera.Clinical trial registry: The study was registered at http://www.clinicaltrials.gov , NCT03135041.

AB - Purpose: The objective of this study was to investigate the additive effects of combining energy restriction with dietary fibres on change in body weight and gut microbiota composition.Methods: The study was a 12-week randomised, placebo-controlled, double-blinded, parallel intervention trial. A total of 116 overweight or obese participants were assigned randomly either to 10 g inulin plus 10 g resistant maltodextrin or to 20 g of placebo supplementation through 400 mL of milk a day, while on a - 500 kcal/day energy restricted diet.Results: Altogether, 86 participants completed the intervention. There were no significant differences in weight loss or body composition between the groups. The fibre supplement reduced systolic (5.35 ± 2.4 mmHg, p = 0.043) and diastolic (2.82 ± 1.3 mmHg, p = 0.047) blood pressure to a larger extent than placebo. Furthermore, a larger decrease in serum insulin was observed in the placebo group compared to the fibre group (- 26.0 ± 9.2 pmol/L, p = 0.006). The intake of fibre induced changes in the composition of gut microbiota resulting in higher abundances of Parabacteroides and Bifidobacteria, compared to placebo. The effects on blood pressure and glucose metabolism were mainly observed in women, and could be attributed to a higher gut microbiota diversity after intervention. Finally, the fibre group experienced a higher degree of gastrointestinal symptoms, which attenuated over time.Conclusions: Supplementation of inulin and resistant maltodextrin did not provide an additional weight loss during an energy-restricted diet, but reduced both systolic and diastolic blood pressure. Furthermore, the fibre supplement did stimulate the growth of potentially beneficial bacteria genera.Clinical trial registry: The study was registered at http://www.clinicaltrials.gov , NCT03135041.

KW - Faculty of Science

KW - Dietary fibre

KW - Gut microbiome

KW - Inulin

KW - Maltodextrin

KW - Obesity

KW - Weight loss

U2 - 10.1007/s00394-019-02099-x

DO - 10.1007/s00394-019-02099-x

M3 - Journal article

C2 - 31605197

SN - 1436-6207

JO - European Journal of Nutrition

JF - European Journal of Nutrition

ER -

The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention

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