The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial

Caecilie Böck Buhmann; Merete Nordentoft; Morten Ekstrøm; Jessica Mariana Carlsson Lohmann; Erik Lykke Mortensen

doi:10.1192/bjp.bp.114.150961

The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial

Caecilie Böck Buhmann, Merete Nordentoft, Morten Ekstrøm, Jessica Mariana Carlsson Lohmann, Erik Lykke Mortensen

46 Citationer (Scopus)

Abstract

BACKGROUND: Little evidence exists on the treatment of traumatised refugees.

AIMS: To estimate treatment effects of flexible cognitive-behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.

METHOD: Randomised controlled clinical trial with 2 × 2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.

RESULTS: A total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.

CONCLUSIONS: In a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.

Originalsprog	Engelsk
Tidsskrift	British Journal of Psychiatry
Vol/bind	208
Udgave nummer	3
Sider (fra-til)	252-9
Antal sider	8
ISSN	0007-1250
DOI	https://doi.org/10.1192/bjp.bp.114.150961
Status	Udgivet - mar. 2016

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10.1192/bjp.bp.114.150961

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Citationsformater

Buhmann, C. B., Nordentoft, M., Ekstrøm, M., Lohmann, J. M. C., & Mortensen, E. L. (2016). The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial. British Journal of Psychiatry, 208(3), 252-9. https://doi.org/10.1192/bjp.bp.114.150961

The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees : pragmatic randomised controlled clinical trial. / Buhmann, Caecilie Böck; Nordentoft, Merete; Ekstrøm, Morten et al.

I: British Journal of Psychiatry, Bind 208, Nr. 3, 03.2016, s. 252-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Buhmann, CB, Nordentoft, M, Ekstrøm, M, Lohmann, JMC & Mortensen, EL 2016, 'The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial', British Journal of Psychiatry, bind 208, nr. 3, s. 252-9. https://doi.org/10.1192/bjp.bp.114.150961

Buhmann CB, Nordentoft M, Ekstrøm M, Lohmann JMC , Mortensen EL. The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial. British Journal of Psychiatry. 2016 mar.;208(3):252-9. doi: 10.1192/bjp.bp.114.150961

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abstract = "BACKGROUND: Little evidence exists on the treatment of traumatised refugees.AIMS: To estimate treatment effects of flexible cognitive-behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.METHOD: Randomised controlled clinical trial with 2 × 2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.RESULTS: A total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.CONCLUSIONS: In a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.",

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