The effect of alcohol binge drinking in early pregnancy on general intelligence in children

Ulrik S. Kesmodel; H-L Falgreen Eriksen; Mette Underbjerg; Tina R. Kilburn; Henrik Støvring; Theresa Wimberley; Erik Lykke Mortensen

doi:10.1111/j.1471-0528.2012.03395.x

The effect of alcohol binge drinking in early pregnancy on general intelligence in children

Ulrik S. Kesmodel, H-L Falgreen Eriksen, Mette Underbjerg, Tina R. Kilburn, Henrik Støvring, Theresa Wimberley, Erik Lykke Mortensen

51 Citationer (Scopus)

Abstract

Please cite this paper as: Kesmodel U, Falgreen Eriksen H, Underbjerg M, Kilburn T, Støvring H, Wimberley T, Mortensen E. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012;119:1222-1231. Objective To examine the effects of binge alcohol consumption during early pregnancy, including the number of binge episodes and the timing of binge drinking, on general intelligence in 5-year-old children. Design Follow-up study. Setting Neuropsychological testing in four Danish cities 2003-2008. Population A cohort of 1617 women and their children sampled from the Danish National Birth Cohort. Methods Participants were sampled on the basis of maternal alcohol consumption during pregnancy. At 5 years of age the children were tested with six subtests from the Wechsler Preschool and Primary Scale of Intelligence - Revised (WPPSI-R). Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, the gender of the child, and tester were considered core confounding factors, whereas the full model also controlled for prenatal maternal average alcohol intake, maternal age, maternal pre-pregnancy body mass index (BMI), parity, home environment, postnatal parental smoking, health status, and indicators for hearing and vision impairment. Main outcome measure WPPSI-R. Results There were no systematic or significant differences in general intelligence between children of mothers reporting binge drinking and children of mothers with no binge episodes, except that binge drinking in gestational weeks 1-2 significantly reduced the risk of low, full-scale IQ (OR 0.54; 95% CI 0.31-0.96) when adjusted for core confounding factors. The results were otherwise not statistically significantly related to the number of binge episodes (with a maximum of 12) and timing of binge drinking. Conclusions We found no systematic association between binge drinking during early pregnancy and child intelligence. However, binge drinking reduced the risk of low, full-scale IQ in gestational weeks 1-2. This finding may be explained by residual confounding.

Originalsprog	Engelsk
Tidsskrift	B J O G
Vol/bind	119
Udgave nummer	10
Sider (fra-til)	1222-31
Antal sider	10
ISSN	1470-0328
DOI	https://doi.org/10.1111/j.1471-0528.2012.03395.x
Status	Udgivet - sep. 2012

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10.1111/j.1471-0528.2012.03395.x

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title = "The effect of alcohol binge drinking in early pregnancy on general intelligence in children",

abstract = "Please cite this paper as: Kesmodel U, Falgreen Eriksen H, Underbjerg M, Kilburn T, St{\o}vring H, Wimberley T, Mortensen E. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012;119:1222-1231. Objective To examine the effects of binge alcohol consumption during early pregnancy, including the number of binge episodes and the timing of binge drinking, on general intelligence in 5-year-old children. Design Follow-up study. Setting Neuropsychological testing in four Danish cities 2003-2008. Population A cohort of 1617 women and their children sampled from the Danish National Birth Cohort. Methods Participants were sampled on the basis of maternal alcohol consumption during pregnancy. At 5 years of age the children were tested with six subtests from the Wechsler Preschool and Primary Scale of Intelligence - Revised (WPPSI-R). Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, the gender of the child, and tester were considered core confounding factors, whereas the full model also controlled for prenatal maternal average alcohol intake, maternal age, maternal pre-pregnancy body mass index (BMI), parity, home environment, postnatal parental smoking, health status, and indicators for hearing and vision impairment. Main outcome measure WPPSI-R. Results There were no systematic or significant differences in general intelligence between children of mothers reporting binge drinking and children of mothers with no binge episodes, except that binge drinking in gestational weeks 1-2 significantly reduced the risk of low, full-scale IQ (OR 0.54; 95% CI 0.31-0.96) when adjusted for core confounding factors. The results were otherwise not statistically significantly related to the number of binge episodes (with a maximum of 12) and timing of binge drinking. Conclusions We found no systematic association between binge drinking during early pregnancy and child intelligence. However, binge drinking reduced the risk of low, full-scale IQ in gestational weeks 1-2. This finding may be explained by residual confounding.",

author = "Kesmodel, {Ulrik S.} and Eriksen, {H-L Falgreen} and Mette Underbjerg and Kilburn, {Tina R.} and Henrik St{\o}vring and Theresa Wimberley and Mortensen, {Erik Lykke}",

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T1 - The effect of alcohol binge drinking in early pregnancy on general intelligence in children

AU - Kesmodel, Ulrik S.

AU - Eriksen, H-L Falgreen

AU - Underbjerg, Mette

AU - Kilburn, Tina R.

AU - Støvring, Henrik

AU - Wimberley, Theresa

AU - Mortensen, Erik Lykke

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N2 - Please cite this paper as: Kesmodel U, Falgreen Eriksen H, Underbjerg M, Kilburn T, Støvring H, Wimberley T, Mortensen E. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012;119:1222-1231. Objective To examine the effects of binge alcohol consumption during early pregnancy, including the number of binge episodes and the timing of binge drinking, on general intelligence in 5-year-old children. Design Follow-up study. Setting Neuropsychological testing in four Danish cities 2003-2008. Population A cohort of 1617 women and their children sampled from the Danish National Birth Cohort. Methods Participants were sampled on the basis of maternal alcohol consumption during pregnancy. At 5 years of age the children were tested with six subtests from the Wechsler Preschool and Primary Scale of Intelligence - Revised (WPPSI-R). Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, the gender of the child, and tester were considered core confounding factors, whereas the full model also controlled for prenatal maternal average alcohol intake, maternal age, maternal pre-pregnancy body mass index (BMI), parity, home environment, postnatal parental smoking, health status, and indicators for hearing and vision impairment. Main outcome measure WPPSI-R. Results There were no systematic or significant differences in general intelligence between children of mothers reporting binge drinking and children of mothers with no binge episodes, except that binge drinking in gestational weeks 1-2 significantly reduced the risk of low, full-scale IQ (OR 0.54; 95% CI 0.31-0.96) when adjusted for core confounding factors. The results were otherwise not statistically significantly related to the number of binge episodes (with a maximum of 12) and timing of binge drinking. Conclusions We found no systematic association between binge drinking during early pregnancy and child intelligence. However, binge drinking reduced the risk of low, full-scale IQ in gestational weeks 1-2. This finding may be explained by residual confounding.

AB - Please cite this paper as: Kesmodel U, Falgreen Eriksen H, Underbjerg M, Kilburn T, Støvring H, Wimberley T, Mortensen E. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012;119:1222-1231. Objective To examine the effects of binge alcohol consumption during early pregnancy, including the number of binge episodes and the timing of binge drinking, on general intelligence in 5-year-old children. Design Follow-up study. Setting Neuropsychological testing in four Danish cities 2003-2008. Population A cohort of 1617 women and their children sampled from the Danish National Birth Cohort. Methods Participants were sampled on the basis of maternal alcohol consumption during pregnancy. At 5 years of age the children were tested with six subtests from the Wechsler Preschool and Primary Scale of Intelligence - Revised (WPPSI-R). Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, the gender of the child, and tester were considered core confounding factors, whereas the full model also controlled for prenatal maternal average alcohol intake, maternal age, maternal pre-pregnancy body mass index (BMI), parity, home environment, postnatal parental smoking, health status, and indicators for hearing and vision impairment. Main outcome measure WPPSI-R. Results There were no systematic or significant differences in general intelligence between children of mothers reporting binge drinking and children of mothers with no binge episodes, except that binge drinking in gestational weeks 1-2 significantly reduced the risk of low, full-scale IQ (OR 0.54; 95% CI 0.31-0.96) when adjusted for core confounding factors. The results were otherwise not statistically significantly related to the number of binge episodes (with a maximum of 12) and timing of binge drinking. Conclusions We found no systematic association between binge drinking during early pregnancy and child intelligence. However, binge drinking reduced the risk of low, full-scale IQ in gestational weeks 1-2. This finding may be explained by residual confounding.

U2 - 10.1111/j.1471-0528.2012.03395.x

DO - 10.1111/j.1471-0528.2012.03395.x

M3 - Journal article

C2 - 22712770

SN - 0140-7686

VL - 119

SP - 1222

EP - 1231

JO - The Journal of obstetrics and gynaecology of the British Commonwealth

JF - The Journal of obstetrics and gynaecology of the British Commonwealth

IS - 10

ER -

The effect of alcohol binge drinking in early pregnancy on general intelligence in children

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