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The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases
Anna Mosbech,
Claudia Lukas
,
Simon Bekker-Jensen
,
Niels Mailand
The NNF Center for Protein Research
Damage and Repair
Center for Sund Aldring
82
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Keyphrases
RNF168
100%
DNA Double-strand Breaks
100%
Double-strand Break Response
100%
RNF8
100%
USP44
100%
Ubiquitin Ligase
100%
Deubiquitinating Enzyme
100%
Double-strand Breaks
57%
USP29
42%
53BP1
28%
Ubiquitin
28%
Ubiquitylation
28%
RING Finger
14%
Accruals
14%
Ubiquitin Conjugates
14%
Protein Recruitment
14%
Enzyme Overexpression
14%
Overexpressing
14%
Functional Redundancy
14%
Negative Regulation
14%
Histone H2A
14%
USP3
14%
OTUB1
14%
Cellular Response
14%
Chromatin
14%
Deubiquitylation
14%
Enhanced Accumulation
14%
Non-specific Reactivity
14%
Protein Assembly
14%
Biochemistry, Genetics and Molecular Biology
Ubiquitin Ligase
100%
Deubiquitylating Enzyme
100%
Double-Strand DNA Break
100%
RNF8
100%
Ubiquitin
42%
Ubiquitination
28%
Conjugate
14%
Protein Assembly
14%
Histone H2A
14%