The copper metallome in prokaryotic cells

TY - CHAP

T1 - The copper metallome in prokaryotic cells

AU - Rensing, Christopher Günther T

AU - Alwathnani, Hend A.

AU - McDevitt, Sylvia F.

PY - 2016

Y1 - 2016

N2 - While all organisms have to balance the intracellular concentrations of transition metals, bacteria harboring additional or highly effective metal detoxification systems have a competitive advantage. The same is true for pathogens, especially since it now has been shown that macrophages and protozoans also utilize heavy metals such as copper and zinc in the killing of phagocytized bacteria. It seems, therefore, not surprising that many bacteria including pathogens harbor additional copper resistance determinants. However, the occurrence of these resistance determinants is more widespread than would be expected by just looking at copper contamination and therefore raises the question of the evolutionary origin.

AB - While all organisms have to balance the intracellular concentrations of transition metals, bacteria harboring additional or highly effective metal detoxification systems have a competitive advantage. The same is true for pathogens, especially since it now has been shown that macrophages and protozoans also utilize heavy metals such as copper and zinc in the killing of phagocytized bacteria. It seems, therefore, not surprising that many bacteria including pathogens harbor additional copper resistance determinants. However, the occurrence of these resistance determinants is more widespread than would be expected by just looking at copper contamination and therefore raises the question of the evolutionary origin.

KW - Copper

KW - Fitness island

KW - Resistance

U2 - 10.1002/9781119004813.ch13

DO - 10.1002/9781119004813.ch13

M3 - Book chapter

AN - SCOPUS:85018828372

SN - 9781119004882

SP - 161

EP - 173

BT - Stress and environmental regulation of gene expression and adaptation in bacteria

A2 - de Bruijn, Frans J.

PB - Wiley

ER -