The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control

TY - JOUR

T1 - The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control

AU - Welsh, Donald G.

AU - Tran, Cam Ha T.

AU - Hald, Bjorn O.

AU - Sancho, Maria

PY - 2018/1/6

Y1 - 2018/1/6

N2 - Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli, sparsely generated in tissue, eliciting electrical responses that conduct lengthwise among electrically coupled vascular cells. The conducted response is the focus of this topical review, and in this regard, the authors highlight literature that advances an appreciation of functional significance, cellular mechanisms, and biophysical principles. Of particular note, this review stresses that conduction is enabled by a defined pattern of charge movement along the arterial wall as set by three key parameters ( tissue structure, gap junctional resistivity, and ion channel activity). The impact of disease on conduction is carefully discussed, as are potential strategies to restore this key biological response and, along with it, the match of blood flow delivery with tissue energetic demand.

AB - Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli, sparsely generated in tissue, eliciting electrical responses that conduct lengthwise among electrically coupled vascular cells. The conducted response is the focus of this topical review, and in this regard, the authors highlight literature that advances an appreciation of functional significance, cellular mechanisms, and biophysical principles. Of particular note, this review stresses that conduction is enabled by a defined pattern of charge movement along the arterial wall as set by three key parameters ( tissue structure, gap junctional resistivity, and ion channel activity). The impact of disease on conduction is carefully discussed, as are potential strategies to restore this key biological response and, along with it, the match of blood flow delivery with tissue energetic demand.

KW - arteries

KW - endothelial cells

KW - gap junctions

KW - ion channels

KW - smooth muscle cells

U2 - 10.1146/annurev-pharmtox-010617-052623

DO - 10.1146/annurev-pharmtox-010617-052623

M3 - Review

C2 - 28968190

SN - 0362-1642

VL - 58

SP - 391

EP - 410

JO - Annual Review of Pharmacology and Toxicology

JF - Annual Review of Pharmacology and Toxicology

ER -