The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model

Vera Russmann; Natalie Seeger; Christina Zellinger; Martin Hadamitzky; Stanislava Pankratova; Hannes Wendt; Elisabeth Bock; Vladimir Berezin; Heidrun Potschka

doi:10.1016/j.neulet.2013.10.003

The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model

Vera Russmann, Natalie Seeger, Christina Zellinger, Martin Hadamitzky, Stanislava Pankratova, Hannes Wendt, Elisabeth Bock, Vladimir Berezin, Heidrun Potschka

3 Citationer (Scopus)

Abstract

Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.

Originalsprog	Engelsk
Tidsskrift	Neuroscience Letters
Vol/bind	556
Sider (fra-til)	170-5
Antal sider	6
ISSN	0304-3940
DOI	https://doi.org/10.1016/j.neulet.2013.10.003
Status	Udgivet - 27 nov. 2013

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10.1016/j.neulet.2013.10.003

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title = "The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model",

abstract = "Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.",

keywords = "Animals, Ciliary Neurotrophic Factor, Female, Hippocampus, Learning, Microglia, Molecular Mimicry, Nerve Degeneration, Neurogenesis, Neurons, Peptide Fragments, Rats, Rats, Sprague-Dawley, Status Epilepticus",

author = "Vera Russmann and Natalie Seeger and Christina Zellinger and Martin Hadamitzky and Stanislava Pankratova and Hannes Wendt and Elisabeth Bock and Vladimir Berezin and Heidrun Potschka",

year = "2013",

month = nov,

day = "27",

doi = "10.1016/j.neulet.2013.10.003",

language = "English",

volume = "556",

pages = "170--5",

journal = "Neuroscience letters. Supplement",

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T1 - The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model

AU - Russmann, Vera

AU - Seeger, Natalie

AU - Zellinger, Christina

AU - Hadamitzky, Martin

AU - Pankratova, Stanislava

AU - Wendt, Hannes

AU - Bock, Elisabeth

AU - Berezin, Vladimir

AU - Potschka, Heidrun

PY - 2013/11/27

Y1 - 2013/11/27

N2 - Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.

AB - Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.

KW - Animals

KW - Ciliary Neurotrophic Factor

KW - Female

KW - Hippocampus

KW - Learning

KW - Microglia

KW - Molecular Mimicry

KW - Nerve Degeneration

KW - Neurogenesis

KW - Neurons

KW - Peptide Fragments

KW - Rats

KW - Rats, Sprague-Dawley

KW - Status Epilepticus

U2 - 10.1016/j.neulet.2013.10.003

DO - 10.1016/j.neulet.2013.10.003

M3 - Journal article

C2 - 24120433

SN - 0167-6253

VL - 556

SP - 170

EP - 175

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

ER -

The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model

Abstract

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