The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection

Neval E Wareham; J D Lundgren; C Da Cunha-Bang; F Gustafsson; M Iversen; H H Johannesen; A Kjær; A Rasmussen; H Sengeløv; S S Sørensen; B M Fischer

doi:10.1007/s00259-016-3564-5

The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection

Neval E Wareham, J D Lundgren, C Da Cunha-Bang, F Gustafsson, M Iversen, H H Johannesen, A Kjær, A Rasmussen, H Sengeløv, S S Sørensen, B M Fischer

8 Citationer (Scopus)

70 Downloads (Pure)

Abstract

PURPOSE: Solid organ transplant (SOT) recipients are at high risk of developing infections and malignancies.18F-FDG PET/CT may enable timely detection of these diseases and help to ensure early intervention. We aimed to describe the clinical utility of FDG PET/CT in consecutive, diagnostic unresolved SOT recipients transplanted from January 2004 to May 2015.

METHODS: Recipients with a post-transplant FDG PET/CT performed as part of diagnostic work-up were included. Detailed chart reviews were done to extract relevant clinical information and determine the final diagnosis related to the FDG PET/CT. Based on á priori defined criteria and the final diagnosis, results from each scan were classified as true or false, and diagnostic values determined.

RESULTS: Among the 1,814 recipients in the cohort, 145 had an FDG PET/CT performed; 122 under the indication of diagnostically unresolved symptoms with a suspicion of malignancy or infection. The remaining (N = 23) had an FDG PET/CT to follow-up on a known disease or to stage a known malignancy. The 122 recipients underwent a total of 133 FDG PET/CT scans performed for a suspected malignancy (66 %) or an infection (34 %). Sensitivity, specificity, and positive and negative predictive values of the FDG PET/CT in diagnosing these conditions were 97, 84, 87, and 96 %, respectively.

CONCLUSION: FDG PET/CT is an accurate diagnostic tool for the work-up of diagnostic unresolved SOT recipients suspected of malignancy or infection. The high sensitivity and NPV underlines the potential usefulness of PET/CT for excluding malignancy or focal infections in this often complex clinical situation.

Originalsprog	Engelsk
Tidsskrift	European Journal of Nuclear Medicine and Molecular Imaging
Vol/bind	44
Udgave nummer	3
Sider (fra-til)	421-431
ISSN	1619-7070
DOI	https://doi.org/10.1007/s00259-016-3564-5
Status	Udgivet - 1 mar. 2017

Adgang til dokumentet

10.1007/s00259-016-3564-5Licens: CC BY

10.1007_s00259-016-3564-5Forlagets udgivne version, 1,27 MBLicens: CC BY

Citationsformater

Wareham, N. E., Lundgren, J. D., Da Cunha-Bang, C., Gustafsson, F., Iversen, M., Johannesen, H. H., Kjær, A., Rasmussen, A., Sengeløv, H., Sørensen, S. S., & Fischer, B. M. (2017). The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection. European Journal of Nuclear Medicine and Molecular Imaging, 44(3), 421-431. https://doi.org/10.1007/s00259-016-3564-5

Wareham, NE, Lundgren, JD, Da Cunha-Bang, C, Gustafsson, F, Iversen, M, Johannesen, HH, Kjær, A, Rasmussen, A, Sengeløv, H , Sørensen, SS & Fischer, BM 2017, 'The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection', European Journal of Nuclear Medicine and Molecular Imaging, bind 44, nr. 3, s. 421-431. https://doi.org/10.1007/s00259-016-3564-5

@article{01538df87a324d529278208fa36a2da9,

title = "The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection",

abstract = "PURPOSE: Solid organ transplant (SOT) recipients are at high risk of developing infections and malignancies.18F-FDG PET/CT may enable timely detection of these diseases and help to ensure early intervention. We aimed to describe the clinical utility of FDG PET/CT in consecutive, diagnostic unresolved SOT recipients transplanted from January 2004 to May 2015.METHODS: Recipients with a post-transplant FDG PET/CT performed as part of diagnostic work-up were included. Detailed chart reviews were done to extract relevant clinical information and determine the final diagnosis related to the FDG PET/CT. Based on {\'a} priori defined criteria and the final diagnosis, results from each scan were classified as true or false, and diagnostic values determined.RESULTS: Among the 1,814 recipients in the cohort, 145 had an FDG PET/CT performed; 122 under the indication of diagnostically unresolved symptoms with a suspicion of malignancy or infection. The remaining (N = 23) had an FDG PET/CT to follow-up on a known disease or to stage a known malignancy. The 122 recipients underwent a total of 133 FDG PET/CT scans performed for a suspected malignancy (66 %) or an infection (34 %). Sensitivity, specificity, and positive and negative predictive values of the FDG PET/CT in diagnosing these conditions were 97, 84, 87, and 96 %, respectively.CONCLUSION: FDG PET/CT is an accurate diagnostic tool for the work-up of diagnostic unresolved SOT recipients suspected of malignancy or infection. The high sensitivity and NPV underlines the potential usefulness of PET/CT for excluding malignancy or focal infections in this often complex clinical situation.",

keywords = "Adult, Female, Fluorodeoxyglucose F18, Humans, Infection/diagnostic imaging, Male, Middle Aged, Neoplasms/diagnostic imaging, Organ Transplantation/adverse effects, Positron Emission Tomography Computed Tomography, Postoperative Complications/diagnostic imaging, Radiopharmaceuticals",

author = "Wareham, {Neval E} and Lundgren, {J D} and {Da Cunha-Bang}, C and F Gustafsson and M Iversen and Johannesen, {H H} and A Kj{\ae}r and A Rasmussen and H Sengel{\o}v and S{\o}rensen, {S S} and Fischer, {B M}",

year = "2017",

month = mar,

day = "1",

doi = "10.1007/s00259-016-3564-5",

language = "English",

volume = "44",

pages = "421--431",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection

AU - Wareham, Neval E

AU - Lundgren, J D

AU - Da Cunha-Bang, C

AU - Gustafsson, F

AU - Iversen, M

AU - Johannesen, H H

AU - Kjær, A

AU - Rasmussen, A

AU - Sengeløv, H

AU - Sørensen, S S

AU - Fischer, B M

PY - 2017/3/1

Y1 - 2017/3/1

N2 - PURPOSE: Solid organ transplant (SOT) recipients are at high risk of developing infections and malignancies.18F-FDG PET/CT may enable timely detection of these diseases and help to ensure early intervention. We aimed to describe the clinical utility of FDG PET/CT in consecutive, diagnostic unresolved SOT recipients transplanted from January 2004 to May 2015.METHODS: Recipients with a post-transplant FDG PET/CT performed as part of diagnostic work-up were included. Detailed chart reviews were done to extract relevant clinical information and determine the final diagnosis related to the FDG PET/CT. Based on á priori defined criteria and the final diagnosis, results from each scan were classified as true or false, and diagnostic values determined.RESULTS: Among the 1,814 recipients in the cohort, 145 had an FDG PET/CT performed; 122 under the indication of diagnostically unresolved symptoms with a suspicion of malignancy or infection. The remaining (N = 23) had an FDG PET/CT to follow-up on a known disease or to stage a known malignancy. The 122 recipients underwent a total of 133 FDG PET/CT scans performed for a suspected malignancy (66 %) or an infection (34 %). Sensitivity, specificity, and positive and negative predictive values of the FDG PET/CT in diagnosing these conditions were 97, 84, 87, and 96 %, respectively.CONCLUSION: FDG PET/CT is an accurate diagnostic tool for the work-up of diagnostic unresolved SOT recipients suspected of malignancy or infection. The high sensitivity and NPV underlines the potential usefulness of PET/CT for excluding malignancy or focal infections in this often complex clinical situation.

AB - PURPOSE: Solid organ transplant (SOT) recipients are at high risk of developing infections and malignancies.18F-FDG PET/CT may enable timely detection of these diseases and help to ensure early intervention. We aimed to describe the clinical utility of FDG PET/CT in consecutive, diagnostic unresolved SOT recipients transplanted from January 2004 to May 2015.METHODS: Recipients with a post-transplant FDG PET/CT performed as part of diagnostic work-up were included. Detailed chart reviews were done to extract relevant clinical information and determine the final diagnosis related to the FDG PET/CT. Based on á priori defined criteria and the final diagnosis, results from each scan were classified as true or false, and diagnostic values determined.RESULTS: Among the 1,814 recipients in the cohort, 145 had an FDG PET/CT performed; 122 under the indication of diagnostically unresolved symptoms with a suspicion of malignancy or infection. The remaining (N = 23) had an FDG PET/CT to follow-up on a known disease or to stage a known malignancy. The 122 recipients underwent a total of 133 FDG PET/CT scans performed for a suspected malignancy (66 %) or an infection (34 %). Sensitivity, specificity, and positive and negative predictive values of the FDG PET/CT in diagnosing these conditions were 97, 84, 87, and 96 %, respectively.CONCLUSION: FDG PET/CT is an accurate diagnostic tool for the work-up of diagnostic unresolved SOT recipients suspected of malignancy or infection. The high sensitivity and NPV underlines the potential usefulness of PET/CT for excluding malignancy or focal infections in this often complex clinical situation.

KW - Adult

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Infection/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Neoplasms/diagnostic imaging

KW - Organ Transplantation/adverse effects

KW - Positron Emission Tomography Computed Tomography

KW - Postoperative Complications/diagnostic imaging

KW - Radiopharmaceuticals

U2 - 10.1007/s00259-016-3564-5

DO - 10.1007/s00259-016-3564-5

M3 - Journal article

C2 - 27838763

SN - 1619-7070

VL - 44

SP - 421

EP - 431

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 3

ER -

The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater