The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

TY - JOUR

T1 - The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

AU - Zhang, Lianbo

AU - Chiang, Wen-Chi

AU - Gao, Qingguo

AU - Givskov, Michael

AU - Tolker-Nielsen, Tim

AU - Yang, Liang

AU - Zhang, Guang

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Bacteria form complex surface-attached biofilm communities in nature. Biofilm cells differentiate into subpopulations which display tolerance towards antimicrobial agents. However, the signal transduction pathways regulating subpopulation differentiation in biofilms are largely unelucidated. In the present study, we show that the catabolite repression control protein Crc regulates the metabolic state of Pseudomonas aeruginosa cells in biofilms, and plays an important role in the development of antimicrobial-tolerant subpopulations in P. aeruginosa biofilms.

AB - Bacteria form complex surface-attached biofilm communities in nature. Biofilm cells differentiate into subpopulations which display tolerance towards antimicrobial agents. However, the signal transduction pathways regulating subpopulation differentiation in biofilms are largely unelucidated. In the present study, we show that the catabolite repression control protein Crc regulates the metabolic state of Pseudomonas aeruginosa cells in biofilms, and plays an important role in the development of antimicrobial-tolerant subpopulations in P. aeruginosa biofilms.

U2 - 10.1099/mic.0.061192-0

DO - 10.1099/mic.0.061192-0

M3 - Journal article

C2 - 23023972

SN - 1350-0872

VL - 158

SP - 3014

EP - 3019

JO - Microbiology

JF - Microbiology

IS - 12

ER -