The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest: a post hoc analysis of the Target Temperature Management trial

TY - JOUR

T1 - The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest

T2 - a post hoc analysis of the Target Temperature Management trial

AU - Annborn, Martin

AU - Bro-Jeppesen, John

AU - Nielsen, Niklas

AU - Ullén, Susann

AU - Kjaergaard, Jesper

AU - Hassager, Christian

AU - Wanscher, Michael

AU - Hovdenes, Jan

AU - Pellis, Tommaso

AU - Pelosi, Paolo

AU - Wise, Matt P

AU - Cronberg, Tobias

AU - Erlinge, David

AU - Friberg, Hans

AU - TTM-trial investigators

PY - 2014/9

Y1 - 2014/9

N2 - Purpose: We hypothesized that a targeted temperature of 33°C as compared to that of 36°C would increase survival and reduce the severity of circulatory shock in patients with shock on admission after out-of-hospital cardiac arrest (OHCA). Methods: The recently published Target Temperature Management trial (TTM-trial) randomized 939 OHCA patients with no difference in outcome between groups and no difference in mortality at the end of the trial in a predefined subgroup of patients with shock at admission. Shock was defined as a systolic blood pressure of <90 mm Hg for >30 min or the need of supportive measures to maintain a blood pressure ≥90 mmHg and/or clinical signs of end-organ hypoperfusion. In this post hoc analysis reported here, we further analyzed the 139 patients with shock at admission; all had been randomized to receive intervention at 33°C (TTM33; n = 71) or 36°C (TTM36; n = 68). Primary outcome was 180-day mortality. Secondary outcomes were intensive care unit (ICU) and 30-day mortality, severity of circulatory shock assessed by mean arterial pressure, serum lactate, fluid balance and the extended Sequential Organ Failure assessment (SOFA) score. Results: There was no significance difference between targeted temperature management at 33°C or 36°C on 180-day mortality [log-rank test, p = 0.17, hazard ratio 1.33, 95 % confidence interval (CI) 0.88-1.98] or ICU mortality (61 vs. 44 %, p = 0.06; relative risk 1.37, 95 % CI 0.99-1.91). Serum lactate and the extended cardiovascular SOFA score were higher in the TTM33 group (p < 0.01). Conclusions: We found no benefit in survival or severity of circulatory shock with targeted temperature management at 33°C as compared to 36°C in patients with shock on admission after OHCA.

AB - Purpose: We hypothesized that a targeted temperature of 33°C as compared to that of 36°C would increase survival and reduce the severity of circulatory shock in patients with shock on admission after out-of-hospital cardiac arrest (OHCA). Methods: The recently published Target Temperature Management trial (TTM-trial) randomized 939 OHCA patients with no difference in outcome between groups and no difference in mortality at the end of the trial in a predefined subgroup of patients with shock at admission. Shock was defined as a systolic blood pressure of <90 mm Hg for >30 min or the need of supportive measures to maintain a blood pressure ≥90 mmHg and/or clinical signs of end-organ hypoperfusion. In this post hoc analysis reported here, we further analyzed the 139 patients with shock at admission; all had been randomized to receive intervention at 33°C (TTM33; n = 71) or 36°C (TTM36; n = 68). Primary outcome was 180-day mortality. Secondary outcomes were intensive care unit (ICU) and 30-day mortality, severity of circulatory shock assessed by mean arterial pressure, serum lactate, fluid balance and the extended Sequential Organ Failure assessment (SOFA) score. Results: There was no significance difference between targeted temperature management at 33°C or 36°C on 180-day mortality [log-rank test, p = 0.17, hazard ratio 1.33, 95 % confidence interval (CI) 0.88-1.98] or ICU mortality (61 vs. 44 %, p = 0.06; relative risk 1.37, 95 % CI 0.99-1.91). Serum lactate and the extended cardiovascular SOFA score were higher in the TTM33 group (p < 0.01). Conclusions: We found no benefit in survival or severity of circulatory shock with targeted temperature management at 33°C as compared to 36°C in patients with shock on admission after OHCA.

KW - Aged

KW - Body Temperature

KW - Female

KW - Hospitalization

KW - Humans

KW - Hypothermia, Induced

KW - Male

KW - Middle Aged

KW - Out-of-Hospital Cardiac Arrest

KW - Severity of Illness Index

KW - Shock

U2 - 10.1007/s00134-014-3375-8

DO - 10.1007/s00134-014-3375-8

M3 - Journal article

C2 - 25001475

SN - 0935-1701

VL - 40

SP - 1210

EP - 1219

JO - European Journal of Intensive Care Medicine

JF - European Journal of Intensive Care Medicine

IS - 9

ER -