TY - JOUR
T1 - The Association of Reproductive Hormone Levels and All-Cause, Cancer, and Cardiovascular Disease Mortality in Men
AU - Agergaard Holmboe, Stine
AU - Vradi, Eleni
AU - Jensen, Tina Kold
AU - Linneberg, Allan
AU - Husemoen, Lise Lotte Nystrup
AU - Scheike, Thomas
AU - Skakkebæk, Niels E
AU - Juul, Anders
AU - Andersson, Anna-Maria
PY - 2015/12
Y1 - 2015/12
N2 - Context: Testosterone (T) levels have been associated with mortality, but controversy exists. Objective: Our objective was to investigate associations between serum levels of total T, SHBG, free T, estradiol, LH and FSH, and subsequent mortality with up to 30 years of follow-up. Design: This was a prospective cohort study consisting of men participating in four independent population-based surveys (MONICA I-III and Inter99) from 1982 to 2001 and followed until December 2012 with complete registry follow-up. Setting and Participants:Atotal of 5350 randomly selectedmenfrom the general population aged 30, 40, 50, 60, or 70 years at baseline participated. Main Outcomes and Measures: All-cause mortality, cardiovascular disease (CVD) mortality, and cancer mortality were the main outcomes. Results: A total of 1533 men died during the follow-up period; 428 from CVD and 480 from cancer. Cox proportional hazard models revealed that men in highest LH quartile had an increased allcause mortality compared to lowest quartile (hazard ratio [HR], 1.32; 95% confidence interval [CI], 1.14-1.53). Likewise, increased quartiles of LH/T and estradiol increased the risk of all-cause mortality (HR, 1.23;95%CI, 1.06-1.43; HR, 1.23;95%CI 1.06-1.43).Noassociation to T levels was found. Higher LH levels were associated with increased cancer mortality (HR, 1.42; 95% CI, 1.10-1.84) independently of smoking status. Lower CVD mortality was seen for men with T in the highest quartile compared to lowest (HR, 0.72;95%CI, 0.53-0.98). Furthermore, negative trends were seen for SHBG and free T in relation to CVD mortality, however insignificant. Conclusion: The observed positive association of LH and LH/T, but not T, with all-cause mortality suggests that a compensated impaired Leydig cell function may be a risk factor for death by all causes in men. Our findings underpin the clinical importance of including LH measurement in the diagnostic work-up of male patients seeking help for possible androgen insufficiency.
AB - Context: Testosterone (T) levels have been associated with mortality, but controversy exists. Objective: Our objective was to investigate associations between serum levels of total T, SHBG, free T, estradiol, LH and FSH, and subsequent mortality with up to 30 years of follow-up. Design: This was a prospective cohort study consisting of men participating in four independent population-based surveys (MONICA I-III and Inter99) from 1982 to 2001 and followed until December 2012 with complete registry follow-up. Setting and Participants:Atotal of 5350 randomly selectedmenfrom the general population aged 30, 40, 50, 60, or 70 years at baseline participated. Main Outcomes and Measures: All-cause mortality, cardiovascular disease (CVD) mortality, and cancer mortality were the main outcomes. Results: A total of 1533 men died during the follow-up period; 428 from CVD and 480 from cancer. Cox proportional hazard models revealed that men in highest LH quartile had an increased allcause mortality compared to lowest quartile (hazard ratio [HR], 1.32; 95% confidence interval [CI], 1.14-1.53). Likewise, increased quartiles of LH/T and estradiol increased the risk of all-cause mortality (HR, 1.23;95%CI, 1.06-1.43; HR, 1.23;95%CI 1.06-1.43).Noassociation to T levels was found. Higher LH levels were associated with increased cancer mortality (HR, 1.42; 95% CI, 1.10-1.84) independently of smoking status. Lower CVD mortality was seen for men with T in the highest quartile compared to lowest (HR, 0.72;95%CI, 0.53-0.98). Furthermore, negative trends were seen for SHBG and free T in relation to CVD mortality, however insignificant. Conclusion: The observed positive association of LH and LH/T, but not T, with all-cause mortality suggests that a compensated impaired Leydig cell function may be a risk factor for death by all causes in men. Our findings underpin the clinical importance of including LH measurement in the diagnostic work-up of male patients seeking help for possible androgen insufficiency.
U2 - 10.1210/jc.2015-2460
DO - 10.1210/jc.2015-2460
M3 - Journal article
C2 - 26488309
SN - 0021-972X
VL - 100
SP - 4472
EP - 4480
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 12
ER -
