The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal: a case control study

Roger C K Tine; Magatte Ndiaye; Helle Holm Hansson; Cheikh T Ndour; Babacar Faye; Michael Alifrangis; K Sylla; Jean L Ndiaye; Pascal Magnussen; Ib C Bygbjerg; Oumar Gaye

doi:10.1186/1756-0500-5-565

The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal: a case control study

Roger C K Tine, Magatte Ndiaye, Helle Holm Hansson, Cheikh T Ndour, Babacar Faye, Michael Alifrangis, K Sylla, Jean L Ndiaye, Pascal Magnussen, Ib C Bygbjerg, Oumar Gaye

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Abstract

BACKGROUND:Malaria and anaemia (Haemoglobin= 11 g/dl. For each participant, a physical examination was done and anthropometric data collected prior to a biological assessment which included: malaria parasitaemia infection, intestinal worm carriage, G6PD deficiency, sickle cell disorders, and alpha-talassaemia.RESULTS:Three hundred and fifty two children 5 years (aOR=0.03, 95%CI0.01-0.08]). Stratified by age group, anaemia was significantly associated with stunting in children less than 5 years (aOR=3.1 95%CI1.4 -- 6.8]), with, sickle cell disorders (aOR=3.5 95%CI 1.4 -- 9.0]), alpha-thalassemia (or=2.4 95%CI1.1--5.3]) and stunting (aOR=3.6 95%CI 1.6--8.2]) for children above 5 years. No association was found between G6PD deficiency, intestinal worm carriage and children's gender.CONCLUSION:Malaria parasitaemia, stunting and haemoglobin genetic disorders represented the major causes of anaemia among study participants. Anaemia control in this area could be achieved by developing integrated interventions targeting both malaria and malnutrition.

Originalsprog	Engelsk
Tidsskrift	BMC Research Notes
Vol/bind	5
Udgave nummer	1
Sider (fra-til)	565
Antal sider	1
ISSN	1756-0500
DOI	https://doi.org/10.1186/1756-0500-5-565
Status	Udgivet - 2012

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10.1186/1756-0500-5-565

The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in SenegalForlagets udgivne version, 368 KB

http://www.biomedcentral.com/1756-0500/5/565

Citationsformater

Tine, R. C. K., Ndiaye, M., Hansson, H. H., Ndour, C. T., Faye, B., Alifrangis, M., Sylla, K., Ndiaye, J. L., Magnussen, P., Bygbjerg, I. C., & Gaye, O. (2012). The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal: a case control study. BMC Research Notes, 5(1), 565. https://doi.org/10.1186/1756-0500-5-565

Tine, RCK, Ndiaye, M, Hansson, HH, Ndour, CT, Faye, B, Alifrangis, M, Sylla, K, Ndiaye, JL, Magnussen, P , Bygbjerg, IC & Gaye, O 2012, 'The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal: a case control study', BMC Research Notes, bind 5, nr. 1, s. 565. https://doi.org/10.1186/1756-0500-5-565

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title = "The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal: a case control study",

abstract = "BACKGROUND:Malaria and anaemia (Haemoglobin= 11 g/dl. For each participant, a physical examination was done and anthropometric data collected prior to a biological assessment which included: malaria parasitaemia infection, intestinal worm carriage, G6PD deficiency, sickle cell disorders, and alpha-talassaemia.RESULTS:Three hundred and fifty two children 5 years (aOR=0.03, 95%CI0.01-0.08]). Stratified by age group, anaemia was significantly associated with stunting in children less than 5 years (aOR=3.1 95%CI1.4 -- 6.8]), with, sickle cell disorders (aOR=3.5 95%CI 1.4 -- 9.0]), alpha-thalassemia (or=2.4 95%CI1.1--5.3]) and stunting (aOR=3.6 95%CI 1.6--8.2]) for children above 5 years. No association was found between G6PD deficiency, intestinal worm carriage and children's gender.CONCLUSION:Malaria parasitaemia, stunting and haemoglobin genetic disorders represented the major causes of anaemia among study participants. Anaemia control in this area could be achieved by developing integrated interventions targeting both malaria and malnutrition.",

keywords = "Anemia, Anemia, Sickle Cell, Animals, Case-Control Studies, Child, Child, Preschool, Entamoeba, Erythrocytes, Female, Giardia lamblia, Glucosephosphate Dehydrogenase, Hemoglobins, Humans, Infant, Malaria, Male, Malnutrition, Parasitemia, Polymorphism, Genetic, Risk Factors, Schistosoma haematobium, Schistosoma mansoni, Senegal, Strongyloides stercoralis, alpha-Thalassemia",

author = "Tine, {Roger C K} and Magatte Ndiaye and Hansson, {Helle Holm} and Ndour, {Cheikh T} and Babacar Faye and Michael Alifrangis and K Sylla and Ndiaye, {Jean L} and Pascal Magnussen and Bygbjerg, {Ib C} and Oumar Gaye",

year = "2012",

doi = "10.1186/1756-0500-5-565",

language = "English",

volume = "5",

pages = "565",

journal = "BMC Research Notes",

issn = "1756-0500",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal

T2 - a case control study

AU - Tine, Roger C K

AU - Ndiaye, Magatte

AU - Hansson, Helle Holm

AU - Ndour, Cheikh T

AU - Faye, Babacar

AU - Alifrangis, Michael

AU - Sylla, K

AU - Ndiaye, Jean L

AU - Magnussen, Pascal

AU - Bygbjerg, Ib C

AU - Gaye, Oumar

PY - 2012

Y1 - 2012

N2 - BACKGROUND:Malaria and anaemia (Haemoglobin= 11 g/dl. For each participant, a physical examination was done and anthropometric data collected prior to a biological assessment which included: malaria parasitaemia infection, intestinal worm carriage, G6PD deficiency, sickle cell disorders, and alpha-talassaemia.RESULTS:Three hundred and fifty two children 5 years (aOR=0.03, 95%CI0.01-0.08]). Stratified by age group, anaemia was significantly associated with stunting in children less than 5 years (aOR=3.1 95%CI1.4 -- 6.8]), with, sickle cell disorders (aOR=3.5 95%CI 1.4 -- 9.0]), alpha-thalassemia (or=2.4 95%CI1.1--5.3]) and stunting (aOR=3.6 95%CI 1.6--8.2]) for children above 5 years. No association was found between G6PD deficiency, intestinal worm carriage and children's gender.CONCLUSION:Malaria parasitaemia, stunting and haemoglobin genetic disorders represented the major causes of anaemia among study participants. Anaemia control in this area could be achieved by developing integrated interventions targeting both malaria and malnutrition.

AB - BACKGROUND:Malaria and anaemia (Haemoglobin= 11 g/dl. For each participant, a physical examination was done and anthropometric data collected prior to a biological assessment which included: malaria parasitaemia infection, intestinal worm carriage, G6PD deficiency, sickle cell disorders, and alpha-talassaemia.RESULTS:Three hundred and fifty two children 5 years (aOR=0.03, 95%CI0.01-0.08]). Stratified by age group, anaemia was significantly associated with stunting in children less than 5 years (aOR=3.1 95%CI1.4 -- 6.8]), with, sickle cell disorders (aOR=3.5 95%CI 1.4 -- 9.0]), alpha-thalassemia (or=2.4 95%CI1.1--5.3]) and stunting (aOR=3.6 95%CI 1.6--8.2]) for children above 5 years. No association was found between G6PD deficiency, intestinal worm carriage and children's gender.CONCLUSION:Malaria parasitaemia, stunting and haemoglobin genetic disorders represented the major causes of anaemia among study participants. Anaemia control in this area could be achieved by developing integrated interventions targeting both malaria and malnutrition.

KW - Anemia

KW - Anemia, Sickle Cell

KW - Animals

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Entamoeba

KW - Erythrocytes

KW - Female

KW - Giardia lamblia

KW - Glucosephosphate Dehydrogenase

KW - Hemoglobins

KW - Humans

KW - Infant

KW - Malaria

KW - Male

KW - Malnutrition

KW - Parasitemia

KW - Polymorphism, Genetic

KW - Risk Factors

KW - Schistosoma haematobium

KW - Schistosoma mansoni

KW - Senegal

KW - Strongyloides stercoralis

KW - alpha-Thalassemia

U2 - 10.1186/1756-0500-5-565

DO - 10.1186/1756-0500-5-565

M3 - Journal article

C2 - 23057857

SN - 1756-0500

VL - 5

SP - 565

JO - BMC Research Notes

JF - BMC Research Notes

IS - 1

ER -