The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

TY - JOUR

T1 - The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

AU - Broedbaek, Kasper

AU - Siersma, Volkert Dirk

AU - Andersen, Jon T

AU - Petersen, Morten

AU - Afzal, Shoaib

AU - Hjelvang, Brian

AU - Weimann, Allan

AU - Semba, Richard D

AU - Ferrucci, Luigi

AU - Poulsen, Henrik E

PY - 2011/4/1

Y1 - 2011/4/1

N2 - This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.

AB - This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.

U2 - 10.3109/10715762.2010.538391

DO - 10.3109/10715762.2010.538391

M3 - Journal article

C2 - 21275071

SN - 1071-5762

VL - 45

SP - 409

EP - 416

JO - Free Radical Research

JF - Free Radical Research

IS - 4

ER -