The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission

E Petersen; B Høgh; Morten Hanefeld Dziegiel; M Borre; A Björkman; N T Marbiah; E Dolopaye; A P Hanson; S Jepsen

The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission

E Petersen, B Høgh, Morten Hanefeld Dziegiel, M Borre, A Björkman, N T Marbiah, E Dolopaye, A P Hanson, S Jepsen

6 Citationer (Scopus)

Abstract

The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.

Originalsprog	Engelsk
Tidsskrift	Acta Tropica
Vol/bind	51
Udgave nummer	2
Sider (fra-til)	135-42
Antal sider	8
ISSN	0001-706X
Status	Udgivet - jun. 1992

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title = "The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission",

abstract = "The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.",

keywords = "Adolescent, Adult, Amino Acid Sequence, Animals, Antibodies, Protozoan, Female, Humans, Immunoglobulin G, Immunoglobulin M, Malaria, Falciparum, Male, Molecular Sequence Data, Plasmodium falciparum, Protozoan Proteins",

author = "E Petersen and B H{\o}gh and Dziegiel, {Morten Hanefeld} and M Borre and A Bj{\"o}rkman and Marbiah, {N T} and E Dolopaye and Hanson, {A P} and S Jepsen",

year = "1992",

month = jun,

language = "English",

volume = "51",

pages = "135--42",

journal = "Acta Tropica",

issn = "0001-706X",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission

AU - Petersen, E

AU - Høgh, B

AU - Dziegiel, Morten Hanefeld

AU - Borre, M

AU - Björkman, A

AU - Marbiah, N T

AU - Dolopaye, E

AU - Hanson, A P

AU - Jepsen, S

PY - 1992/6

Y1 - 1992/6

N2 - The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.

AB - The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.

KW - Adolescent

KW - Adult

KW - Amino Acid Sequence

KW - Animals

KW - Antibodies, Protozoan

KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Immunoglobulin M

KW - Malaria, Falciparum

KW - Male

KW - Molecular Sequence Data

KW - Plasmodium falciparum

KW - Protozoan Proteins

M3 - Journal article

C2 - 1354931

SN - 0001-706X

VL - 51

SP - 135

EP - 142

JO - Acta Tropica

JF - Acta Tropica

IS - 2

ER -

The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission

Abstract

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