The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

Laura M. Thornton; Melissa A. Munn-Chernoff; Jessica H. Baker; Anders Juréus; Richard Parker; Anjali K. Henders; Janne T. Larsen; Liselotte Petersen; Hunna J. Watson; Zeynep Yilmaz; Katherine M. Kirk; Scott Gordon; Virpi M. Leppä; Felicity C. Martin; David C. Whiteman; Catherine M. Olsen; Thomas M. Werge; Nancy L. Pedersen; Walter Kaye; Andrew W. Bergen; Katherine A. Halmi; Michael Strober; Allan S. Kaplan; D. Blake Woodside; James Mitchell; Craig L. Johnson; Harry Brandt; Steven Crawford; L. John Horwood; Joseph M. Boden; John F. Pearson; Laramie E. Duncan; Jakob Grove; Manuel Mattheisen; Jennifer Jordan; Martin A. Kennedy; Andreas Birgegård; Paul Lichtenstein; Claes Norring; Tracey D. Wade; Grant W. Montgomery; Nicholas G. Martin; Mikael Landén; Preben Bo Mortensen; Patrick F. Sullivan; Cynthia M. Bulik

doi:10.1016/j.cct.2018.09.015

The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

Laura M. Thornton, Melissa A. Munn-Chernoff, Jessica H. Baker, Anders Juréus, Richard Parker, Anjali K. Henders, Janne T. Larsen, Liselotte Petersen, Hunna J. Watson, Zeynep Yilmaz, Katherine M. Kirk, Scott Gordon, Virpi M. Leppä, Felicity C. Martin, David C. Whiteman, Catherine M. Olsen, Thomas M. Werge, Nancy L. Pedersen, Walter Kaye, Andrew W. BergenKatherine A. Halmi, Michael Strober, Allan S. Kaplan, D. Blake Woodside, James Mitchell, Craig L. Johnson, Harry Brandt, Steven Crawford, L. John Horwood, Joseph M. Boden, John F. Pearson, Laramie E. Duncan, Jakob Grove, Manuel Mattheisen, Jennifer Jordan, Martin A. Kennedy, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Tracey D. Wade, Grant W. Montgomery, Nicholas G. Martin, Mikael Landén, Preben Bo Mortensen, Patrick F. Sullivan, Cynthia M. Bulik^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

17 Citationer (Scopus)

Abstract

Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

Originalsprog	Engelsk
Tidsskrift	Contemporary Clinical Trials
Vol/bind	74
Sider (fra-til)	61-69
Antal sider	9
ISSN	1551-7144
DOI	https://doi.org/10.1016/j.cct.2018.09.015
Status	Udgivet - 2018

Adgang til dokumentet

10.1016/j.cct.2018.09.015

Citationsformater

Thornton, L. M., Munn-Chernoff, M. A., Baker, J. H., Juréus, A., Parker, R., Henders, A. K., Larsen, J. T., Petersen, L., Watson, H. J., Yilmaz, Z., Kirk, K. M., Gordon, S., Leppä, V. M., Martin, F. C., Whiteman, D. C., Olsen, C. M., Werge, T. M., Pedersen, N. L., Kaye, W., ... Bulik, C. M. (2018). The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. Contemporary Clinical Trials, 74, 61-69. https://doi.org/10.1016/j.cct.2018.09.015

Thornton, LM, Munn-Chernoff, MA, Baker, JH, Juréus, A, Parker, R, Henders, AK, Larsen, JT, Petersen, L, Watson, HJ, Yilmaz, Z, Kirk, KM, Gordon, S, Leppä, VM, Martin, FC, Whiteman, DC, Olsen, CM, Werge, TM, Pedersen, NL, Kaye, W, Bergen, AW, Halmi, KA, Strober, M, Kaplan, AS, Woodside, DB, Mitchell, J, Johnson, CL, Brandt, H, Crawford, S, Horwood, LJ, Boden, JM, Pearson, JF, Duncan, LE, Grove, J, Mattheisen, M, Jordan, J, Kennedy, MA, Birgegård, A, Lichtenstein, P, Norring, C, Wade, TD, Montgomery, GW, Martin, NG, Landén, M, Mortensen, PB, Sullivan, PF & Bulik, CM 2018, 'The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods', Contemporary Clinical Trials, bind 74, s. 61-69. https://doi.org/10.1016/j.cct.2018.09.015

@article{a09a0630f6444f638342d9284f105909,

title = "The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods",

abstract = "Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.",

keywords = "Anorexia nervosa, Eating disorders, Genome-wide association, Psychiatric genetics, Psychiatric genomics consortium, Social media",

author = "Thornton, {Laura M.} and Munn-Chernoff, {Melissa A.} and Baker, {Jessica H.} and Anders Jur{\'e}us and Richard Parker and Henders, {Anjali K.} and Larsen, {Janne T.} and Liselotte Petersen and Watson, {Hunna J.} and Zeynep Yilmaz and Kirk, {Katherine M.} and Scott Gordon and Lepp{\"a}, {Virpi M.} and Martin, {Felicity C.} and Whiteman, {David C.} and Olsen, {Catherine M.} and Werge, {Thomas M.} and Pedersen, {Nancy L.} and Walter Kaye and Bergen, {Andrew W.} and Halmi, {Katherine A.} and Michael Strober and Kaplan, {Allan S.} and Woodside, {D. Blake} and James Mitchell and Johnson, {Craig L.} and Harry Brandt and Steven Crawford and Horwood, {L. John} and Boden, {Joseph M.} and Pearson, {John F.} and Duncan, {Laramie E.} and Jakob Grove and Manuel Mattheisen and Jennifer Jordan and Kennedy, {Martin A.} and Andreas Birgeg{\aa}rd and Paul Lichtenstein and Claes Norring and Wade, {Tracey D.} and Montgomery, {Grant W.} and Martin, {Nicholas G.} and Mikael Land{\'e}n and Mortensen, {Preben Bo} and Sullivan, {Patrick F.} and Bulik, {Cynthia M.}",

year = "2018",

doi = "10.1016/j.cct.2018.09.015",

language = "English",

volume = "74",

pages = "61--69",

journal = "Contemporary Clinical Trials",

issn = "1551-7144",

publisher = "Elsevier",

}

TY - JOUR

T1 - The Anorexia Nervosa Genetics Initiative (ANGI)

T2 - Overview and methods

AU - Thornton, Laura M.

AU - Munn-Chernoff, Melissa A.

AU - Baker, Jessica H.

AU - Juréus, Anders

AU - Parker, Richard

AU - Henders, Anjali K.

AU - Larsen, Janne T.

AU - Petersen, Liselotte

AU - Watson, Hunna J.

AU - Yilmaz, Zeynep

AU - Kirk, Katherine M.

AU - Gordon, Scott

AU - Leppä, Virpi M.

AU - Martin, Felicity C.

AU - Whiteman, David C.

AU - Olsen, Catherine M.

AU - Werge, Thomas M.

AU - Pedersen, Nancy L.

AU - Kaye, Walter

AU - Bergen, Andrew W.

AU - Halmi, Katherine A.

AU - Strober, Michael

AU - Kaplan, Allan S.

AU - Woodside, D. Blake

AU - Mitchell, James

AU - Johnson, Craig L.

AU - Brandt, Harry

AU - Crawford, Steven

AU - Horwood, L. John

AU - Boden, Joseph M.

AU - Pearson, John F.

AU - Duncan, Laramie E.

AU - Grove, Jakob

AU - Mattheisen, Manuel

AU - Jordan, Jennifer

AU - Kennedy, Martin A.

AU - Birgegård, Andreas

AU - Lichtenstein, Paul

AU - Norring, Claes

AU - Wade, Tracey D.

AU - Montgomery, Grant W.

AU - Martin, Nicholas G.

AU - Landén, Mikael

AU - Mortensen, Preben Bo

AU - Sullivan, Patrick F.

AU - Bulik, Cynthia M.

PY - 2018

Y1 - 2018

N2 - Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

AB - Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

KW - Anorexia nervosa

KW - Eating disorders

KW - Genome-wide association

KW - Psychiatric genetics

KW - Psychiatric genomics consortium

KW - Social media

U2 - 10.1016/j.cct.2018.09.015

DO - 10.1016/j.cct.2018.09.015

M3 - Journal article

C2 - 30287268

AN - SCOPUS:85054436931

SN - 1551-7144

VL - 74

SP - 61

EP - 69

JO - Contemporary Clinical Trials

JF - Contemporary Clinical Trials

ER -

The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater