Terapi med stamceller til akut iskaemisk hjertesygdom, myokardial regeneration?

TY - JOUR

T1 - Terapi med stamceller til akut iskaemisk hjertesygdom, myokardial regeneration?

AU - Ripa, Rasmus Sejersten

AU - Wang, Yongzhong

AU - Jørgensen, Erik

AU - Kastrup, Jens

PY - 2007/1/8

Y1 - 2007/1/8

N2 - Treatment of ischemic heart disease with injections of bone-marrow-derived stem cells is a promising new modality. However, recent medium-sized placebo controlled trials in patients with acute myocardial infarction have not been conclusive regarding the treatment effect. This short review aims to elucidate some of the unresolved issues raised by the first clinical trials. These include long-term safety, tissue-distribution of infused cells, selecting the optimal cell type and number, timing of the treatment, and the mechanism of a potential treatment effect.

AB - Treatment of ischemic heart disease with injections of bone-marrow-derived stem cells is a promising new modality. However, recent medium-sized placebo controlled trials in patients with acute myocardial infarction have not been conclusive regarding the treatment effect. This short review aims to elucidate some of the unresolved issues raised by the first clinical trials. These include long-term safety, tissue-distribution of infused cells, selecting the optimal cell type and number, timing of the treatment, and the mechanism of a potential treatment effect.

KW - Clinical Trials as Topic

KW - Heart

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Myocardial Ischemia

KW - Regeneration

KW - Treatment Outcome

M3 - Tidsskriftartikel

C2 - 17227657

SN - 0041-5782

VL - 169

SP - 119

EP - 122

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 2

ER -