Abstract
Therapeutic vaccines is a novel approach in castration-resistant prostate cancer treatment
Castration-resistant prostate cancer (CRPC) is defined as tumour progression despite castrate levels of serum testosterone. During the past decade a number of new therapies, including chemotherapy and novel endocrine agents have been approved for CRPC treatment. The continued need for new effective drugs in CRPC has led to development of a novel therapeutic approach in CRPC treatment. Therapeutic vaccines activate the immune system to kill prostate cancer cells. This review describes recent pivotal phase 2 and 3 trials of CRPC vaccines and discusses the impact on future CRPC management.
Castration-resistant prostate cancer (CRPC) is defined as tumour progression despite castrate levels of serum testosterone. During the past decade a number of new therapies, including chemotherapy and novel endocrine agents have been approved for CRPC treatment. The continued need for new effective drugs in CRPC has led to development of a novel therapeutic approach in CRPC treatment. Therapeutic vaccines activate the immune system to kill prostate cancer cells. This review describes recent pivotal phase 2 and 3 trials of CRPC vaccines and discusses the impact on future CRPC management.
Bidragets oversatte titel | Therapeutic vaccines is a novel approach in castration-resistant prostate cancer treatment |
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Originalsprog | Dansk |
Artikelnummer | 22 |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 177 |
Udgave nummer | 22 |
Sider (fra-til) | 2-7 |
Antal sider | 6 |
ISSN | 0041-5782 |
Status | Udgivet - 11 maj 2015 |