Ten-year retrospective study of head and neck carcinoma in situ: incidence, treatment, and clinical outcome

Anders Christensen; Elisabeth Kristensen; M H Therkildsen; L Specht; Jesper Reibel; Preben Homøe

doi:10.1016/j.oooo.2013.03.002

Ten-year retrospective study of head and neck carcinoma in situ: incidence, treatment, and clinical outcome

Anders Christensen, Elisabeth Kristensen, M H Therkildsen, L Specht, Jesper Reibel, Preben Homøe

6 Citationer (Scopus)

Abstract

Objectives: To examine the management and clinical outcome for patients with primary head and neck carcinoma in situ (CIS) and to estimate the incidence in the referral population. Study design: A retrospective study from 2000-2009 of patients with head and neck CIS referred for treatment at Rigshospitalet. The referral area was East Denmark and Greenland with a population of 2.4 million. Results: Fifty-five patients with primary CIS were identified: 21 oral cavity, 7 pharynx, 25 larynx, 2 nasal cavity/paranasal sinuses. The median annual incidence was 0.24/100,000. Eleven patients (20%) had T-site recurrence. The 5-year disease-specific survival rate and 5-year recurrence-free survival rate were 98% and 74% respectively. Conclusions: The annual incidence of primary head and neck CIS was low and in accordance with previous findings reported in the literature. We recommend that CIS lesions should be treated on T-site and surveilled as T1/T2 head and neck carcinomas.

Originalsprog	Engelsk
Tidsskrift	Oral and Maxillofacial Surgery
Vol/bind	116
Udgave nummer	2
Sider (fra-til)	174-178
Antal sider	5
ISSN	1865-1550
DOI	https://doi.org/10.1016/j.oooo.2013.03.002
Status	Udgivet - aug. 2013

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10.1016/j.oooo.2013.03.002

Citationsformater

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title = "Ten-year retrospective study of head and neck carcinoma in situ: incidence, treatment, and clinical outcome",

abstract = "Objectives: To examine the management and clinical outcome for patients with primary head and neck carcinoma in situ (CIS) and to estimate the incidence in the referral population. Study design: A retrospective study from 2000-2009 of patients with head and neck CIS referred for treatment at Rigshospitalet. The referral area was East Denmark and Greenland with a population of 2.4 million. Results: Fifty-five patients with primary CIS were identified: 21 oral cavity, 7 pharynx, 25 larynx, 2 nasal cavity/paranasal sinuses. The median annual incidence was 0.24/100,000. Eleven patients (20%) had T-site recurrence. The 5-year disease-specific survival rate and 5-year recurrence-free survival rate were 98% and 74% respectively. Conclusions: The annual incidence of primary head and neck CIS was low and in accordance with previous findings reported in the literature. We recommend that CIS lesions should be treated on T-site and surveilled as T1/T2 head and neck carcinomas.",

author = "Anders Christensen and Elisabeth Kristensen and Therkildsen, {M H} and L Specht and Jesper Reibel and Preben Hom{\o}e",

year = "2013",

month = aug,

doi = "10.1016/j.oooo.2013.03.002",

language = "English",

volume = "116",

pages = "174--178",

journal = "Oral and Maxillofacial Surgery",

issn = "1865-1550",

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TY - JOUR

T1 - Ten-year retrospective study of head and neck carcinoma in situ

T2 - incidence, treatment, and clinical outcome

AU - Christensen, Anders

AU - Kristensen, Elisabeth

AU - Therkildsen, M H

AU - Specht, L

AU - Reibel, Jesper

AU - Homøe, Preben

PY - 2013/8

Y1 - 2013/8

N2 - Objectives: To examine the management and clinical outcome for patients with primary head and neck carcinoma in situ (CIS) and to estimate the incidence in the referral population. Study design: A retrospective study from 2000-2009 of patients with head and neck CIS referred for treatment at Rigshospitalet. The referral area was East Denmark and Greenland with a population of 2.4 million. Results: Fifty-five patients with primary CIS were identified: 21 oral cavity, 7 pharynx, 25 larynx, 2 nasal cavity/paranasal sinuses. The median annual incidence was 0.24/100,000. Eleven patients (20%) had T-site recurrence. The 5-year disease-specific survival rate and 5-year recurrence-free survival rate were 98% and 74% respectively. Conclusions: The annual incidence of primary head and neck CIS was low and in accordance with previous findings reported in the literature. We recommend that CIS lesions should be treated on T-site and surveilled as T1/T2 head and neck carcinomas.

AB - Objectives: To examine the management and clinical outcome for patients with primary head and neck carcinoma in situ (CIS) and to estimate the incidence in the referral population. Study design: A retrospective study from 2000-2009 of patients with head and neck CIS referred for treatment at Rigshospitalet. The referral area was East Denmark and Greenland with a population of 2.4 million. Results: Fifty-five patients with primary CIS were identified: 21 oral cavity, 7 pharynx, 25 larynx, 2 nasal cavity/paranasal sinuses. The median annual incidence was 0.24/100,000. Eleven patients (20%) had T-site recurrence. The 5-year disease-specific survival rate and 5-year recurrence-free survival rate were 98% and 74% respectively. Conclusions: The annual incidence of primary head and neck CIS was low and in accordance with previous findings reported in the literature. We recommend that CIS lesions should be treated on T-site and surveilled as T1/T2 head and neck carcinomas.

U2 - 10.1016/j.oooo.2013.03.002

DO - 10.1016/j.oooo.2013.03.002

M3 - Journal article

C2 - 23643320

SN - 1865-1550

VL - 116

SP - 174

EP - 178

JO - Oral and Maxillofacial Surgery

JF - Oral and Maxillofacial Surgery

IS - 2

ER -

Ten-year retrospective study of head and neck carcinoma in situ: incidence, treatment, and clinical outcome

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