Ten year neurocognitive trajectories in first-episode psychosis

Helene E Barder; Kjetil Sundet; Bjørn R Rund; Julie Evensen; Ulrik Haahr; Wenche Ten Velden Hegelstad; Inge Joa; Jan O Johannessen; Johannes Langeveld; Tor K Larsen; Ingrid Melle; Stein Opjordsmoen; Jan I Røssberg; Erik Simonsen; Per Vaglum; Thomas McGlashan; Svein Friis

doi:10.3389/fnhum.2013.00643

Ten year neurocognitive trajectories in first-episode psychosis

Helene E Barder, Kjetil Sundet, Bjørn R Rund, Julie Evensen, Ulrik Haahr, Wenche Ten Velden Hegelstad, Inge Joa, Jan O Johannessen, Johannes Langeveld, Tor K Larsen, Ingrid Melle, Stein Opjordsmoen, Jan I Røssberg, Erik Simonsen, Per Vaglum, Thomas McGlashan, Svein Friis

Institut for Klinisk Medicin

35 Citationer (Scopus)

Abstract

Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory. Method: Forty-three FEP subjects (51% male, 28 ± 9 years) were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year. Results: The four neurocognitive indices showed overall stability over the 10 year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year [F (4, 38) = 5.8, p = 0.001, η(2) = 0.40]. Conclusions: Main findings are long-term stability in neurocognitive functioning in FEP patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed.

Originalsprog	Engelsk
Tidsskrift	Frontiers in Human Neuroscience
Vol/bind	7
Sider (fra-til)	643
ISSN	1662-5161
DOI	https://doi.org/10.3389/fnhum.2013.00643
Status	Udgivet - 7 okt. 2013

Adgang til dokumentet

10.3389/fnhum.2013.00643

Citationsformater

Barder, H. E., Sundet, K., Rund, B. R., Evensen, J., Haahr, U., Ten Velden Hegelstad, W., Joa, I., Johannessen, J. O., Langeveld, J., Larsen, T. K., Melle, I., Opjordsmoen, S., Røssberg, J. I., Simonsen, E., Vaglum, P., McGlashan, T., & Friis, S. (2013). Ten year neurocognitive trajectories in first-episode psychosis. Frontiers in Human Neuroscience, 7, 643. https://doi.org/10.3389/fnhum.2013.00643

Barder, HE, Sundet, K, Rund, BR, Evensen, J, Haahr, U, Ten Velden Hegelstad, W, Joa, I, Johannessen, JO, Langeveld, J, Larsen, TK, Melle, I, Opjordsmoen, S, Røssberg, JI, Simonsen, E, Vaglum, P, McGlashan, T & Friis, S 2013, 'Ten year neurocognitive trajectories in first-episode psychosis', Frontiers in Human Neuroscience, bind 7, s. 643. https://doi.org/10.3389/fnhum.2013.00643

@article{1a8ee96c0e1f49c998182f75fbb7da00,

title = "Ten year neurocognitive trajectories in first-episode psychosis",

abstract = "Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory. Method: Forty-three FEP subjects (51% male, 28 ± 9 years) were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year. Results: The four neurocognitive indices showed overall stability over the 10 year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year [F (4, 38) = 5.8, p = 0.001, η(2) = 0.40]. Conclusions: Main findings are long-term stability in neurocognitive functioning in FEP patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed.",

author = "Barder, {Helene E} and Kjetil Sundet and Rund, {Bj{\o}rn R} and Julie Evensen and Ulrik Haahr and {Ten Velden Hegelstad}, Wenche and Inge Joa and Johannessen, {Jan O} and Johannes Langeveld and Larsen, {Tor K} and Ingrid Melle and Stein Opjordsmoen and R{\o}ssberg, {Jan I} and Erik Simonsen and Per Vaglum and Thomas McGlashan and Svein Friis",

year = "2013",

month = oct,

day = "7",

doi = "10.3389/fnhum.2013.00643",

language = "English",

volume = "7",

pages = "643",

journal = "Frontiers in Human Neuroscience",

issn = "1662-5161",

publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Ten year neurocognitive trajectories in first-episode psychosis

AU - Barder, Helene E

AU - Sundet, Kjetil

AU - Rund, Bjørn R

AU - Evensen, Julie

AU - Haahr, Ulrik

AU - Ten Velden Hegelstad, Wenche

AU - Joa, Inge

AU - Johannessen, Jan O

AU - Langeveld, Johannes

AU - Larsen, Tor K

AU - Melle, Ingrid

AU - Opjordsmoen, Stein

AU - Røssberg, Jan I

AU - Simonsen, Erik

AU - Vaglum, Per

AU - McGlashan, Thomas

AU - Friis, Svein

PY - 2013/10/7

Y1 - 2013/10/7

N2 - Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory. Method: Forty-three FEP subjects (51% male, 28 ± 9 years) were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year. Results: The four neurocognitive indices showed overall stability over the 10 year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year [F (4, 38) = 5.8, p = 0.001, η(2) = 0.40]. Conclusions: Main findings are long-term stability in neurocognitive functioning in FEP patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed.

AB - Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory. Method: Forty-three FEP subjects (51% male, 28 ± 9 years) were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year. Results: The four neurocognitive indices showed overall stability over the 10 year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year [F (4, 38) = 5.8, p = 0.001, η(2) = 0.40]. Conclusions: Main findings are long-term stability in neurocognitive functioning in FEP patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed.

U2 - 10.3389/fnhum.2013.00643

DO - 10.3389/fnhum.2013.00643

M3 - Journal article

C2 - 24109449

SN - 1662-5161

VL - 7

SP - 643

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

ER -

Ten year neurocognitive trajectories in first-episode psychosis

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater