Temperate Phages of Staphylococcus aureus

TY - JOUR

T1 - Temperate Phages of Staphylococcus aureus

AU - Ingmer, Hanne

AU - Gerlach, David

AU - Wolz, Christiane

PY - 2019

Y1 - 2019

N2 - Most Staphylococcus aureus isolates carry multiple bacteriophages in their genome, which provide the pathogen with traits important for niche adaptation. Such temperate S. aureus phages often encode a variety of accessory factors that influence virulence, immune evasion and host preference of the bacterial lysogen. Moreover, transducing phages are primary vehicles for horizontal gene transfer. Wall teichoic acid (WTA) acts as a common phage receptor for staphylococcal phages and structural variations of WTA govern phage-host specificity thereby shaping gene transfer across clonal lineages and even species. Thus, bacteriophages are central for the success of S. aureus as a human pathogen.

AB - Most Staphylococcus aureus isolates carry multiple bacteriophages in their genome, which provide the pathogen with traits important for niche adaptation. Such temperate S. aureus phages often encode a variety of accessory factors that influence virulence, immune evasion and host preference of the bacterial lysogen. Moreover, transducing phages are primary vehicles for horizontal gene transfer. Wall teichoic acid (WTA) acts as a common phage receptor for staphylococcal phages and structural variations of WTA govern phage-host specificity thereby shaping gene transfer across clonal lineages and even species. Thus, bacteriophages are central for the success of S. aureus as a human pathogen.

U2 - 10.1128/microbiolspec.GPP3-0058-2018

DO - 10.1128/microbiolspec.GPP3-0058-2018

M3 - Journal article

C2 - 31562736

AN - SCOPUS:85072694301

SN - 2165-0497

VL - 7

SP - 1

EP - 18

JO - Microbiology Spectrum

JF - Microbiology Spectrum

IS - 5

ER -