Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

Frej Fyhrquist; Anders Eriksson; Outi Saijonmaa; Børge G Nordestgaard; Kimmo Kontula; Ulf de Faire; Hans Ibsen; Sverre Kjeldsen; Ingrid Os; Björn Dahlöf

doi:10.1177/1470320312460292

Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

Frej Fyhrquist, Anders Eriksson, Outi Saijonmaa, Børge G Nordestgaard, Kimmo Kontula, Ulf de Faire, Hans Ibsen, Sverre Kjeldsen, Ingrid Os, Björn Dahlöf

7 Citationer (Scopus)

Abstract

INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (

Originalsprog	Engelsk
Tidsskrift	Journal of the Renin-Angiotensin-Aldosterone System
ISSN	1470-3203
DOI	https://doi.org/10.1177/1470320312460292
Status	Udgivet - sep. 2013

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10.1177/1470320312460292

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@article{5fab2d35b3f9421abb87d4b8574ab75b,

title = "Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy",

abstract = "INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (",

author = "Frej Fyhrquist and Anders Eriksson and Outi Saijonmaa and Nordestgaard, {B{\o}rge G} and Kimmo Kontula and {de Faire}, Ulf and Hans Ibsen and Sverre Kjeldsen and Ingrid Os and Bj{\"o}rn Dahl{\"o}f",

year = "2013",

month = sep,

doi = "10.1177/1470320312460292",

language = "English",

journal = "Journal of the Renin-Angiotensin-Aldosterone System",

issn = "1470-3203",

publisher = "Sage Science Press (UK)",

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TY - JOUR

T1 - Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

AU - Fyhrquist, Frej

AU - Eriksson, Anders

AU - Saijonmaa, Outi

AU - Nordestgaard, Børge G

AU - Kontula, Kimmo

AU - de Faire, Ulf

AU - Ibsen, Hans

AU - Kjeldsen, Sverre

AU - Os, Ingrid

AU - Dahlöf, Björn

PY - 2013/9

Y1 - 2013/9

N2 - INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (

AB - INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (

U2 - 10.1177/1470320312460292

DO - 10.1177/1470320312460292

M3 - Journal article

C2 - 23077078

SN - 1470-3203

JO - Journal of the Renin-Angiotensin-Aldosterone System

JF - Journal of the Renin-Angiotensin-Aldosterone System

ER -

Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

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