T-lymphocyte subset dynamics in well-treated HIV-infected men during a bout of exhausting exercise

TY - JOUR

T1 - T-lymphocyte subset dynamics in well-treated HIV-infected men during a bout of exhausting exercise

AU - Dirksen, Carsten

AU - Hansen, Birgitte R

AU - Kolte, Lilian

AU - Haugaard, Steen B

AU - Andersen, Ove

PY - 2015

Y1 - 2015

N2 - In healthy individuals the substantial lymphocytosis during a bout of exhausting exercise constitutes primarily mature T cells from the peripheral lymphoid organs but naive T cells are also recruited. This study investigated whether the defective CD4 + T-lymphocyte count in peripheral blood during rest in human immunodeficiency virus (HIV)-infected patients would also be observed following a maximal output ergometer bicycle test. At rest, in 45 well-treated HIV-infected patients, mature and naive CD4 + T-lymphocyte counts were decreased whereas the less immune active CD8 + T lymphocytes were increased compared with 10 healthy control subjects. In response to exercise mature and naive CD4 + T lymphocytes increased less and mature and naive CD8 + T lymphocytes increased most in HIV-infected patients. In conclusion, defective resting mature and naive CD4 + T lymphocytes in well-treated HIV-infected patients are also reflected in defective acutely mobilized active immune cells following exhausting exercise. The CD4 + T-lymphocyte count is highly sensitive to physical activity.

AB - In healthy individuals the substantial lymphocytosis during a bout of exhausting exercise constitutes primarily mature T cells from the peripheral lymphoid organs but naive T cells are also recruited. This study investigated whether the defective CD4 + T-lymphocyte count in peripheral blood during rest in human immunodeficiency virus (HIV)-infected patients would also be observed following a maximal output ergometer bicycle test. At rest, in 45 well-treated HIV-infected patients, mature and naive CD4 + T-lymphocyte counts were decreased whereas the less immune active CD8 + T lymphocytes were increased compared with 10 healthy control subjects. In response to exercise mature and naive CD4 + T lymphocytes increased less and mature and naive CD8 + T lymphocytes increased most in HIV-infected patients. In conclusion, defective resting mature and naive CD4 + T lymphocytes in well-treated HIV-infected patients are also reflected in defective acutely mobilized active immune cells following exhausting exercise. The CD4 + T-lymphocyte count is highly sensitive to physical activity.

U2 - 10.3109/23744235.2015.1069392

DO - 10.3109/23744235.2015.1069392

M3 - Journal article

C2 - 26244875

SN - 2374-4235

VL - 47

SP - 919

EP - 923

JO - Infectious Diseases

JF - Infectious Diseases

IS - 12

ER -