Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy

Anders Jorgensen; Jesper Krogh; Kamilla Miskowiak; Tom G Bolwig; Lars V Kessing; Anders Fink-Jensen; Merete Nordentoft; Trine Henriksen; Allan Weimann; Henrik E Poulsen; Martin B Jorgensen

doi:10.1016/j.jad.2013.02.011

Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy

Anders Jorgensen, Jesper Krogh, Kamilla Miskowiak, Tom G Bolwig, Lars V Kessing, Anders Fink-Jensen, Merete Nordentoft, Trine Henriksen, Allan Weimann, Henrik E Poulsen, Martin B Jorgensen

51 Citationer (Scopus)

Abstract

Background: Depression has been associated with increased oxidative stress and hypothesized to accelerate aging. Nucleic acid damage from oxidation is a critical part of the aging process, and a suggested early event in age-related somatic morbidities that are also prevalent in depression, such as dementia and type 2 diabetes. We hypothesized that increased severity of depression is associated with increased systemic oxidatively generated DNA and RNA damage, and that this increase is attenuated by an effective antidepressant treatment. Methods: The urinary excretion of markers of systemic oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo), respectively, were determined in healthy controls (N=28), moderately depressed, non-medicated patients (N=26) and severely depressed patients eligible for electroconvulsive therapy (ECT) (N=29). In the severely depressed patient group, samples were also obtained 1 week after the completion of ECT. Results: Systemic RNA damage from oxidation, as measured by 8-oxoGuo excretion, was higher with increasing severity of depression (controls<moderately depressed<severely depressed) (P for trend=0.004). The 8-oxoGuo excretion was further increased after clinically effective ECT compared with pre-ECT values (P=0.006). There were no differences in 8-oxodG excretion between the groups or pre- vs. post-ECT. Limitations: Small sample size and the inclusion of both unipolar and bipolar patients in the severely depressed group. Conclusions: Severe depression is associated with increased systemic oxidatively generated RNA damage, which may be an additional factor underlying the somatic morbidity and neurodegenerative features associated with depression. Due to the lack of normalization by clinically effective ECT, the phenomenon does not appear to be causally linked to the depressive state per se.

Originalsprog	Engelsk
Tidsskrift	Journal of Affective Disorders
Vol/bind	149
Udgave nummer	1-3
Sider (fra-til)	355-362
Antal sider	8
ISSN	0165-0327
DOI	https://doi.org/10.1016/j.jad.2013.02.011
Status	Udgivet - jul. 2013

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10.1016/j.jad.2013.02.011

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Jorgensen, A., Krogh, J., Miskowiak, K., Bolwig, T. G., Kessing, L. V., Fink-Jensen, A., Nordentoft, M., Henriksen, T., Weimann, A., Poulsen, H. E., & Jorgensen, M. B. (2013). Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy. Journal of Affective Disorders, 149(1-3), 355-362. https://doi.org/10.1016/j.jad.2013.02.011

Jorgensen, A, Krogh, J , Miskowiak, K, Bolwig, TG, Kessing, LV , Fink-Jensen, A , Nordentoft, M, Henriksen, T, Weimann, A, Poulsen, HE & Jorgensen, MB 2013, 'Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy', Journal of Affective Disorders, bind 149, nr. 1-3, s. 355-362. https://doi.org/10.1016/j.jad.2013.02.011

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title = "Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy",

abstract = "Background: Depression has been associated with increased oxidative stress and hypothesized to accelerate aging. Nucleic acid damage from oxidation is a critical part of the aging process, and a suggested early event in age-related somatic morbidities that are also prevalent in depression, such as dementia and type 2 diabetes. We hypothesized that increased severity of depression is associated with increased systemic oxidatively generated DNA and RNA damage, and that this increase is attenuated by an effective antidepressant treatment. Methods: The urinary excretion of markers of systemic oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo), respectively, were determined in healthy controls (N=28), moderately depressed, non-medicated patients (N=26) and severely depressed patients eligible for electroconvulsive therapy (ECT) (N=29). In the severely depressed patient group, samples were also obtained 1 week after the completion of ECT. Results: Systemic RNA damage from oxidation, as measured by 8-oxoGuo excretion, was higher with increasing severity of depression (controls",

keywords = "Adult, Biomarkers, DNA Damage, Deoxyguanosine, Depressive Disorder, Major, Electroconvulsive Therapy, Female, Humans, Male, Middle Aged, Oxidative Stress, RNA, Journal Article, Research Support, Non-U.S. Gov't",

author = "Anders Jorgensen and Jesper Krogh and Kamilla Miskowiak and Bolwig, {Tom G} and Kessing, {Lars V} and Anders Fink-Jensen and Merete Nordentoft and Trine Henriksen and Allan Weimann and Poulsen, {Henrik E} and Jorgensen, {Martin B}",

year = "2013",

month = jul,

doi = "10.1016/j.jad.2013.02.011",

language = "English",

volume = "149",

pages = "355--362",

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T2 - associations to symptom severity and response to electroconvulsive therapy

AU - Jorgensen, Anders

AU - Krogh, Jesper

AU - Miskowiak, Kamilla

AU - Bolwig, Tom G

AU - Kessing, Lars V

AU - Fink-Jensen, Anders

AU - Nordentoft, Merete

AU - Henriksen, Trine

AU - Weimann, Allan

AU - Poulsen, Henrik E

AU - Jorgensen, Martin B

PY - 2013/7

Y1 - 2013/7

N2 - Background: Depression has been associated with increased oxidative stress and hypothesized to accelerate aging. Nucleic acid damage from oxidation is a critical part of the aging process, and a suggested early event in age-related somatic morbidities that are also prevalent in depression, such as dementia and type 2 diabetes. We hypothesized that increased severity of depression is associated with increased systemic oxidatively generated DNA and RNA damage, and that this increase is attenuated by an effective antidepressant treatment. Methods: The urinary excretion of markers of systemic oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo), respectively, were determined in healthy controls (N=28), moderately depressed, non-medicated patients (N=26) and severely depressed patients eligible for electroconvulsive therapy (ECT) (N=29). In the severely depressed patient group, samples were also obtained 1 week after the completion of ECT. Results: Systemic RNA damage from oxidation, as measured by 8-oxoGuo excretion, was higher with increasing severity of depression (controls

AB - Background: Depression has been associated with increased oxidative stress and hypothesized to accelerate aging. Nucleic acid damage from oxidation is a critical part of the aging process, and a suggested early event in age-related somatic morbidities that are also prevalent in depression, such as dementia and type 2 diabetes. We hypothesized that increased severity of depression is associated with increased systemic oxidatively generated DNA and RNA damage, and that this increase is attenuated by an effective antidepressant treatment. Methods: The urinary excretion of markers of systemic oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo), respectively, were determined in healthy controls (N=28), moderately depressed, non-medicated patients (N=26) and severely depressed patients eligible for electroconvulsive therapy (ECT) (N=29). In the severely depressed patient group, samples were also obtained 1 week after the completion of ECT. Results: Systemic RNA damage from oxidation, as measured by 8-oxoGuo excretion, was higher with increasing severity of depression (controls

KW - Adult

KW - Biomarkers

KW - DNA Damage

KW - Deoxyguanosine

KW - Depressive Disorder, Major

KW - Electroconvulsive Therapy

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Oxidative Stress

KW - RNA

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1016/j.jad.2013.02.011

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JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1-3

ER -

Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy

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