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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
Mikko Gynther,
Darryl S Pickering
, Julie Spicer, William Denny, Kristiina Huttunen
17
Citationer (Scopus)
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Keyphrases
Prodrug
100%
L-type Amino Acid Transporter 1 (LAT1)
37%
Therapeutic Potential
12%
Uptake Mechanism
12%
Organic Anion Transporter
12%
Mouse Brain
12%
Transporter Substrate
12%
Central Nervous System
12%
Uptake Rate
12%
Neuroinflammation
12%
Uptake Studies
12%
Brain Uptake
12%
Brain Perfusion
12%
In Vitro Uptake
12%
Astrocytes
12%
Mouse Cortical Neurons
12%
Cortical Astrocytes
12%
Cellular Uptake
12%
Brain Concentration
12%
In Vivo Pharmacokinetics
12%
Bolus Injection
12%
Probenecid
12%
Tryptophan
12%
Area under the Concentration Curve
12%
In Situ
12%
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacokinetic
100%
Perforin
100%
Prodrug
100%
Amino Acid Transporter
37%
Nervous System Inflammation
12%
Polypeptide
12%
Central Nervous System Disease
12%
Tryptophan
12%
Probenecid
12%