@article{ed8f47025e1a4aff813d9cfaba4461d4,
title = "Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice",
abstract = "Breast cancer frequently leads to incurable bone metastasis. Essential requirements for the development of bone metastasis are cell-cell and cell-matrix interactions, release of bioactive growth factors and cytokines, and removal of large amounts of bone matrix. Matrix metalloproteinases (MMPs) play an important role in all of these processes, but the possibility of using synthetic MMP inhibitors to decrease bone metastasis has received little attention.",
keywords = "Animals, Antineoplastic Agents, Bone Neoplasms, Breast Neoplasms, Cell Survival, Dipeptides, Female, Gene Therapy, Humans, Matrix Metalloproteinases, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness, Osteolysis, Phenylalanine, Protease Inhibitors, Thiophenes, Transfection, Transplantation, Heterologous, Tumor Cells, Cultured",
author = "Bent Winding and R{\'o}is{\'i}n NicAmhlaoibh and Henriette Misander and Pernille H{\o}egh-Andersen and Andersen, {Thomas Levin} and Claus Holst-Hansen and Anne-Marie Heegaard and Foged, {Niels Taekker} and Nils Br{\"u}nner and Jean-Marie Delaiss{\'e}",
year = "2002",
language = "English",
volume = "8",
pages = "1932--9",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research (A A C R)",
number = "6",
}
