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Synthesis of Trifluoromethyl Ketone Containing Amino Acid Building Blocks for the Preparation of Peptide-Based Histone Deacetylase (HDAC) Inhibitors
Carlos Moreno-Yruela
,
Christian Adam Olsen
4
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Keyphrases
Amino
50%
Amino Acids
100%
Aqueous Media
25%
Binding Group
25%
Chelates
25%
Class IIa Histone Deacetylases
25%
Electrophilic
25%
Enantiomerically Pure
25%
Enzymatic Activity
25%
Further Development
25%
Gene Regulation
25%
Histone Deacetylase 1 (HDAC1)
25%
Histone Deacetylase Inhibitor (HDACi)
100%
Isozymes
25%
Peptide-based
100%
Protecting Group Strategy
25%
Solid-phase Peptide Synthesis
25%
Synthetic Procedures
25%
Transcription Factor Genes
25%
Trifluoromethyl Ketones
100%
Zn2+
50%
Chemistry
Amino Acid
100%
Diol
33%
Enzyme Activity
33%
Histone
66%
histone deacetylase inhibitor
100%
Ketone
100%
Ketones
100%
Peptide Synthesis
33%
Protecting Group
33%
Purity
33%
Transcription Factor
33%
Biochemistry, Genetics and Molecular Biology
Electrophilicity
25%