Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A

Henrik Franzyk; Søren Rosendal Jensen; Carl Erik Olsen; Jon Holbech Rasmussen

doi:10.1081/NCN-120006528

Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A

Henrik Franzyk, Søren Rosendal Jensen, Carl Erik Olsen, Jon Holbech Rasmussen

6 Citationer (Scopus)

Abstract

Two enantiomerically pure hydroxymethyl substituted cyclopentene nucleoside analogues (42 and 53) related to carbovir and neplanocin A, respectively, were prepared from the chiral pool of iridoid glucosides. In addition two saturated hydroxymethylated analogues (44 and 45) were obtained from a protected intermediate.

Originalsprog	Engelsk
Tidsskrift	Nucleosides, Nucleotides and Nucleic Acids
Vol/bind	21
Udgave nummer	1
Sider (fra-til)	23-43
Antal sider	21
ISSN	1525-7770
DOI	https://doi.org/10.1081/NCN-120006528
Status	Udgivet - 2002
Udgivet eksternt	Ja

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10.1081/NCN-120006528

Citationsformater

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title = "Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A",

abstract = "Two enantiomerically pure hydroxymethyl substituted cyclopentene nucleoside analogues (42 and 53) related to carbovir and neplanocin A, respectively, were prepared from the chiral pool of iridoid glucosides. In addition two saturated hydroxymethylated analogues (44 and 45) were obtained from a protected intermediate.",

keywords = "Adenosine, Dideoxynucleosides, Nucleosides",

author = "Henrik Franzyk and Jensen, {S{\o}ren Rosendal} and Olsen, {Carl Erik} and Rasmussen, {Jon Holbech}",

year = "2002",

doi = "10.1081/NCN-120006528",

language = "English",

volume = "21",

pages = "23--43",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

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TY - JOUR

T1 - Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A

AU - Franzyk, Henrik

AU - Jensen, Søren Rosendal

AU - Olsen, Carl Erik

AU - Rasmussen, Jon Holbech

PY - 2002

Y1 - 2002

N2 - Two enantiomerically pure hydroxymethyl substituted cyclopentene nucleoside analogues (42 and 53) related to carbovir and neplanocin A, respectively, were prepared from the chiral pool of iridoid glucosides. In addition two saturated hydroxymethylated analogues (44 and 45) were obtained from a protected intermediate.

AB - Two enantiomerically pure hydroxymethyl substituted cyclopentene nucleoside analogues (42 and 53) related to carbovir and neplanocin A, respectively, were prepared from the chiral pool of iridoid glucosides. In addition two saturated hydroxymethylated analogues (44 and 45) were obtained from a protected intermediate.

KW - Adenosine

KW - Dideoxynucleosides

KW - Nucleosides

U2 - 10.1081/NCN-120006528

DO - 10.1081/NCN-120006528

M3 - Journal article

C2 - 11991147

SN - 1525-7770

VL - 21

SP - 23

EP - 43

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 1

ER -

Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A

Abstract

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