Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

Andrea Pinto; Paola Conti; Giovanni Grazioso; Lucia Tamborini; Ulf Madsen; Birgitte Nielsen; Carlo De Micheli

doi:10.1016/j.ejmech.2010.12.020

Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

Andrea Pinto, Paola Conti, Giovanni Grazioso, Lucia Tamborini, Ulf Madsen, Birgitte Nielsen, Carlo De Micheli

14 Citationer (Scopus)

Abstract

The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.

Originalsprog	Engelsk
Tidsskrift	European Journal of Medicinal Chemistry
Vol/bind	46
Udgave nummer	2
Sider (fra-til)	787-793
ISSN	0223-5234
DOI	https://doi.org/10.1016/j.ejmech.2010.12.020
Status	Udgivet - 1 feb. 2011

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10.1016/j.ejmech.2010.12.020

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Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors. / Pinto, Andrea; Conti, Paola; Grazioso, Giovanni et al.
I: European Journal of Medicinal Chemistry, Bind 46, Nr. 2, 01.02.2011, s. 787-793.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Andrea Pinto and Paola Conti and Giovanni Grazioso and Lucia Tamborini and Ulf Madsen and Birgitte Nielsen and {De Micheli}, Carlo",

note = "Keywords: glutamic acid, ionotropic Glu receptors, isoxazoline, 1,3-dipolar cycloaddition",

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AU - Pinto, Andrea

AU - Conti, Paola

AU - Grazioso, Giovanni

AU - Tamborini, Lucia

AU - Madsen, Ulf

AU - Nielsen, Birgitte

AU - De Micheli, Carlo

N1 - Keywords: glutamic acid, ionotropic Glu receptors, isoxazoline, 1,3-dipolar cycloaddition

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DO - 10.1016/j.ejmech.2010.12.020

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JF - European Journal of Medicinal Chemistry

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ER -

Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

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