Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers

TY - JOUR

T1 - Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers

AU - Olsen, J. A.

AU - Severinsen, R.

AU - Rasmussen, T. B.

AU - Hentzer, M.

AU - Givskov, M.

AU - Nielsen, J.

AU - Nielsen, John

PY - 2002/2/11

Y1 - 2002/2/11

N2 - The quorum sensing mechanism in Gram-negative bacteria uses small intercellular signal molecules, N-acyl-homoserine lactones (AHLs), to control transcription of specific genes in relation to population density. In this communication, we describe the parallel synthesis of new AHL analogues, in which substituents have been introduced into the 3- and 4-positions of the lactone ring. These analogues have been screened for their ability to activate and inhibit a Vibrio fischeri LuxI/LuxR-derived quorum sensing reporter system.

AB - The quorum sensing mechanism in Gram-negative bacteria uses small intercellular signal molecules, N-acyl-homoserine lactones (AHLs), to control transcription of specific genes in relation to population density. In this communication, we describe the parallel synthesis of new AHL analogues, in which substituents have been introduced into the 3- and 4-positions of the lactone ring. These analogues have been screened for their ability to activate and inhibit a Vibrio fischeri LuxI/LuxR-derived quorum sensing reporter system.

U2 - 10.1016/S0960-894X(01)00756-9

DO - 10.1016/S0960-894X(01)00756-9

M3 - Journal article

C2 - 11814788

AN - SCOPUS:0037059938

SN - 0960-894X

VL - 12

SP - 325

EP - 328

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -