Synthesis of long T silicon nanoparticles for hyperpolarized Si magnetic resonance imaging

TY - JOUR

T1 - Synthesis of long T silicon nanoparticles for hyperpolarized Si magnetic resonance imaging

AU - Atkins, T.M.

AU - Ganguly, S.

AU - Kauzlarich, S.M.

AU - Cassidy, M.C.

AU - Lee, M.

AU - Marcus, C.M.

PY - 2013/2/26

Y1 - 2013/2/26

N2 - We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

AB - We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

UR - http://www.scopus.com/inward/record.url?scp=84874433268&partnerID=8YFLogxK

U2 - 10.1021/nn305462y

DO - 10.1021/nn305462y

M3 - Journal article

C2 - 23350651

AN - SCOPUS:84874433268

SN - 1936-0851

VL - 7

SP - 1609

EP - 1617

JO - A C S Nano

JF - A C S Nano

IS - 2

ER -