Synthesis of L-Tricholomic acid analogues and pharmacological characterization at ionotropic glutamate receptors

TY - JOUR

T1 - Synthesis of L-Tricholomic acid analogues and pharmacological characterization at ionotropic glutamate receptors

AU - Tamborini, Lucia

AU - Mastronardi, Federica

AU - Lo Presti, Leonardo

AU - Nielsen, Birgitte

AU - De Micheli, Carlo

AU - Conti, Paola

AU - Pinto, Andrea

PY - 2017/10/31

Y1 - 2017/10/31

N2 - The synthesis of analogues of the natural compound l-tricholomic acid and of its threo diastereoisomer was accomplished in order to explore their affinity for glutamate ionotropic receptors. In this study, fourteen new unnatural amino acids, characterized by a 3-hydroxy-▵2-isoxazoline or 3-hydroxy-▵2-pyrazoline-skeleton, were obtained exploiting, as key reaction, a 1,3-dipolar cycloaddition or an intramolecular cyclization.

AB - The synthesis of analogues of the natural compound l-tricholomic acid and of its threo diastereoisomer was accomplished in order to explore their affinity for glutamate ionotropic receptors. In this study, fourteen new unnatural amino acids, characterized by a 3-hydroxy-▵2-isoxazoline or 3-hydroxy-▵2-pyrazoline-skeleton, were obtained exploiting, as key reaction, a 1,3-dipolar cycloaddition or an intramolecular cyclization.

U2 - 10.1002/slct.201702154

DO - 10.1002/slct.201702154

M3 - Journal article

SN - 2365-6549

VL - 2

SP - 10295

EP - 10299

JO - ChemistrySelect

JF - ChemistrySelect

IS - 31

ER -